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People seek out cannabis products for any number of reasons. It could be a natural part of their holistic wellness practices, as a supplement to their treatments, or to create a sense of health and wellness, cannabinoid effects are versatile. At Myriam’s Hemp, we believe that hemp and its cannabinoids can have a helpful effect on many people. We’ve created a line of products that make use of these compounds and are easy to include in your day-to-day life. On our blog, you’ll find a variety of resources and insights into cannabinoids, their uses, and their effects. From articles to videos and graphics, there’s a lot to enjoy on our blog.

What Is CBDV?

Reading Time 8 Minutes

What Is CBDV?

The hemp plant contains numerous cannabinoids– life-enhancing chemicals that interact with our bodies endocannabinoid system. Estimates range from 60 to over 140 of these different compounds, and as hemp research continues to develop, we are learning more and more about different cannabinoids every day.

One of these cannabinoids is cannabidivarin or CBDV for short. CBDV was first isolated in Germany in 1969, but research since then has been limited. This is true for many cannabinoids other than CBD. However, the research shows great promise for CBDV as a helpful compound that compliments other cannabinoids. 

CBDV Research

Chemically, we know that CBDV is structurally similar to CBD. It is a homologous molecule to CBD, which means that the basic structure is the same and the two molecules are differentiated by repeating elements such as side chains of different lengths or a peptide residue. In layman’s terms, this means that homologous molecules may have similar properties, and this does seem to be the case with CBD and CBDV. 

Biologically speaking, there are some major differences. CBD is relatively abundant, and commercial hemp strains may contain up to 30% CBD content. CBDV, however, isn’t even found in all strains of hemp. It isn’t even found in all hemp plants, and usually only makes up less than 1% of any hemp plant’s cannabinoid content. 

There are some African landrace strains of hemp that have up to 4% CBDV content, and some hemp breeders have experimented with plants and gotten results of up to 7% CBDV content. But 7% is still a long way from the quantities of CBD hemp plants can naturally produce. Also unlike CBD, CBDV is not easily produced in a lab from precursor compounds. 

Adding to the challenge of acquiring large quantities of CBDV is the fact that it is largely limited to landrace plants. Landrace hemp strains are naturally-growing hemp varieties that have not been crossbred with other strains. These plants must exist in relative isolation and have not been selected for favorable traits like commercially grown strains. CBDV is primarily found in Cannabis indica landrace plants originating in Africa, but it can also be found in somewhat elevated concentrations in indica landrace strains from Pakistan, India, and Mexico. 

While these plants can be farmed, they must be kept away from other plants to avoid the risk of cross-pollination. CBDV production is not a dominant characteristic in hemp plants, and it is a minor cannabinoid with an unknown botanical function. All of this means that there have been major stumbling blocks in researching CBDV. Even though it was first isolated in 1969, the first major research was not undertaken until 2012. There’s a lot that we don’t know yet about CBDV, but the research is very exciting.

Despite the difficulty in getting large quantities of CBDV, research has shown that it has promising effects on health. This is partially in part to how it interacts with the body. Unlike most cannabinoids, it does not react with the endocannabinoid system. Instead, it activates or desensitizes the transient receptor potential channels (TRP channels). The TRP channels play critical roles in managing our sensory systems and allow cells to detect changes in their environment. This system is linked to a number of sensory issues, as well as epilepsy and other types of seizures.

CBDV for Seizures

Beyond its anticonvulsant properties, studies have shown that there is a molecular component to the effectiveness of CBDV for epilepsy. One major study has shown that CBDV is effective in treating seizures from a variety of causes in rodent models. Additionally, CBDV treatment did not impact motor skills after recovery. This is a concern with some anti-seizure medications, and an anticonvulsant that does not cause impairments in motor skills shows potential for long-term use by chronic epilepsy patients. 

In further rodent trials, CBDV has even been shown to have an effect on epilepsy-related gene expression in brain tissues after seizures. The brain tissues’ responses were rapid and acute, and the CBDV seemed to interact directly with the brain instead of just the endocannabinoid system’s receptors. As in other trials, motor skills were also unaffected during post-seizure recovery. This indicates great promise for CBDV as a seizure medication. 

Drug trials for a CBDV-based seizure medication are already in progress. The pharmaceutical company GW Pharmaceuticals, manufacturers of the CBD-based Epidiolex, is currently recruiting for Stage III trials of their CBDV-based anti-convulsant for temporal lobe seizures. 

CBDV and Rett Syndrome

Rett Syndrome is caused by mutations on the X chromosome, it is characterized by the impairment of cognitive, sensory, emotional, motor, and autonomic function. Symptoms include repetitive hand movements, slower brain growth and intellectual disability. A rodent trial found that CBDV may contribute to reversing the deterioration and atrophy of the brain areas involved in Rett syndrome, and human trials demonstrated that a dose of 10 mg per day of CBDV a day significantly reduced seizures. 

Additionally, this trial showed that  Rett Syndrome patients who took CBDV also scored higher in areas including sociability, general health, brain weight, and hormone activity in the hippocampus (the part of the brain responsible for emotion and memory). This suggests that CBDV may also help with the non-seizure aspects of Rett Syndrome.

CBDV and Autism

CBDV has also been investigated for its therapeutic use for people on the autism spectrum. CBDV reacts with the brain’s excitation pathways, which are easily overstimulated and lead to repetitive behaviors that can interfere with an autistic person’s quality of life. CBDV is currently being trialed as a way to help autistic people manage their behavioral symptoms and mental health concerns. Additionally, autism and epilepsy frequently occur together, so a compound that can treat issues stemming from both may be beneficial to many people. 

CBDV also shows promise as a treatment for children with intellectual disabilities and may reduce the number of severe behavioral problems in these children, making it easier to keep them safe and care for them. CBDV is much gentler than sedatives, benzodiazepines, and other depressants. Additionally, it seems to have fewer short term and long term side effects and does not have a long term negative effect on gross motor skills, meaning that is likely a safer alternative to help these children.

Other Benefits of CBDV

Like many other cannabinoids, CBDV is effective at reducing nausea. This has been shown in studies using various animal models and is not surprising given that the first medically approved use for any cannabinoid was for nausea and vomiting. 

CBDV also shows promise as an acne treatment when used topically due to its anti-inflammatory nature. CBDV reduces the buildup of dead skin cells and lipids that form around inflamed skin, which is what causes acne breakouts. This is a topical application of CBDV and other key cannabinoids. 

How To Take CBDV

There is no psychoactive component to CBDV. It will not get you high or cause any kind of motor impairments. However, despite being totally legal in the United States, it can be difficult to find CBDV for sale. This is because landrace hemp strains are not the same things as commercial hemp, and so there are more restrictions around this kind of hemp. Furthermore, landraces typically contain a higher THC content than is allowed to be commercially grown in the United States. This means that acquiring pure therapeutic CBDV can be a challenge. 

We hold the CBDV that we offer here at Myriam’s Hemp to the same high standards of purity and quality that we hold all of our CBD products. You can rest assured that the CBDV we offer is made with natural, organic, high-quality ingredients. This includes our carrier oils, as well as the cannabinoids we offer. All of our products are lab tested and guaranteed to be free of sugars and other fillers.

Our CBDV tincture is best taken like all of our other tinctures. Simply use the dropper to place your dosage under your tongue, or mix it into a beverage if you prefer to take it that way. 

Buy CBDV at Myriam’s Hemp

At Myriam’s Hemp, our goal is to help you make the most of your cannabinoid experience. We believe in our products and want to help you take control of your health by offering premium hemp products, like CBD, CBG, CBN, CBDA, CBGA, and CBDV tinctures and topicals.

Our cannabinoid products are created with quality at the forefront, and we are constantly striving to enhance our offerings. Our products are designed with the goal of providing you with the relief you’re looking for and helping you manage your health without total reliance on traditional pharmaceuticals. Shop Myriam’s Hemp online and order your cannabinoid products today.

References

How To Get Rid of Brain Fog

Reading Time 4 Minutes

Brain fog is a chronic mental syndrome that combines cognitive fatigue, judgment issues, and memory impairment for an overall feeling of discomfort and disorientation. It has garnered attention recently as a symptom of COVID-19. This catch-all term has a number of contributing factors and can be tricky to understand. 

What Is Brain Fog?

Brain fog is the term used to describe a number of symptoms that all contribute to an overall uncomfortable feeling of being “spaced out” or mentally sluggish. Brain fog feels like a lack of mental clarity. When you’re dealing with it, it can be hard to focus or pay attention, and it makes it difficult for you to recall things.

Brain fog doesn’t necessarily hurt and it usually isn’t accompanied by pain. That said, brain fog can lead to additional symptoms, including prolonged or worsened sleep disorders, gastrointestinal dysfunction, and a decreased metabolism.

It can also have wide-ranging effects on your mental and emotional health. Brain fog can be confusing, frustrating, and upsetting. It can make problems seem much worse and make you feel like you’re losing control over small details, which is often quite distressing.

What Causes Brain Fog

There are lots of contributing factors to brain fog. It can be the result of numerous health conditions, including hormonal conditions and chronic health conditions. The following conditions are all associated with brain fog:

  • Insomnia
  • Stress
  • Dementia
  • Depression and other mental illnesses
  • Medication side effects
  • Thyroid disorders
  • Multiple sclerosis
  • Migraines
  • Cancer
  • Chronic inflammation
  • Head injuries
  • Nutrient deficiencies 
  • Chronic fatigue syndrome
  • Menopause
  • Viral infections, including COVID-19 

How Can CBD and CBDA Help With Brain Fog?

Because brain fog has so many different causes, we don’t know how many people suffer from it. However, neuroscientists point out that about 600 million people suffer from cognitive dysfunction. 

Cognitive dysfunction is a symptom that many people choose to address with CBD or CBDA. Studies have shown that CBD has therapeutic effects on many different areas of the brain, improving limbic system activity, cognitive pattern recognition, and overall performance of cognitive tasks and functions.

This is likely because of how CBD interacts with receptors in the body’s endocannabinoid system. The endocannabinoid system is a biological system that impacts your mood, pain sensation, mental function, and various other important bodily functions. CBDA also has impacts on your mood and mental function, but it works somewhat differently than CBD. 

CBDA interacts with our serotonin system, and through its interactions with this neurotransmitter, CBDA can have a powerful effect on the mind. CBDA is the precursor to CBD and is less well-known than CBD. Both CBD and CBDA can help fight brain fog, but they do so using different chemical receptors and signal mechanisms.

While less is known about everything that CBDA can do, CBD works to fight brain fog in a number of ways. Here are some of the ways that cannabinoids like CBD can directly impact brain fog.

Cannabinoids Reduce Inflammation

Research has shown that CBD can reduce inflammation throughout the body. Inflammation is linked directly to brain fog, especially in patients with post-COVID-19 neurological symptoms

Cannabinoids Promote Good Sleep

Sleep deprivation is a common root issue of brain fog, and CBD in particular has performed well in recent studies relating to sleep regulation.

Cannabinoids Reduce Anxiety

The use of CBD influences the activity in certain parts of your brain that are connected to stress, depression, and anxiety. The same is true of CBDA as it interacts with your serotonin system. A reduction in anxiety can improve your overall brain function, and research shows that CBD and CBDA are helpful for people with anxiety.

Boost Your CBD Tincture

More than half of all CBD users take the cannabinoid to address mental health concerns. A full-spectrum CBD tincture like our Daily 50 CBD Oil or our Premium CBDA Oil will engage the cannabinoid receptors in your brain and may lead to improved cognitive function, including improved memory, clarity, and focus.

If you want to take CBD or CBDA specifically to address the “fuzzy” feelings of brain fog, you can choose to add the Focus Terpene Boost blend to any of our tinctures. This is a proprietary blend of specific terpenes that are geared to enhance your experience by improving focus, clarity, and cognitive function. Simply scroll down before you add your tincture to your shopping cart and choose the Focus Terpene Boost– it’s that easy.

Buy CBD and CBDA at Myriam’s Hemp

At Myriam’s Hemp, we want to help you improve your life and make the most of your cannabinoid experience. Our goal is to provide hope to those who are suffering from conditions that can have a significantly negative impact on everyday life. Our cannabinoid tinctures and topicals are created with quality ingredients that may provide you with the relief you’re looking for. Shop Myriam’s Hemp online and order your cannabinoid products today.

CBG for Anxiety & Mental Health

Reading Time 5 Minutes

Cannabis and hemp possess a virtually infinite potential for the world of health and wellness and have already proven to be both physically and psychologically beneficial by amateur and anecdotal experience and scientific investigation. Cannabigerolic acid—also known as CBGA—is one of the many derivative byproducts of hemp, and emerging studies are beginning to highlight its amazing benefits in the realm of mental health.

What are CBGA and CBG?

Before we dig into how CBGA and CBG can help your brain, let’s take a quick look at what they are and how they work.

Both CBG and CBGA are cannabinoids, and they share this classification with better-known cannabis derivatives, like THC and CBD. In its acidic form, CBGA (sometimes written as CBG-A) breaks down into one of the many cannabinoids. In some instances, it may break down into CBG.

Right now, CBG research is in its infancy. Compared to many of the other cannabinoids, it hasn’t seen as much scientific or social interest. However, with technology and efforts surrounding cannabis legalization growing daily, more studies are being conducted on CBGA and CBG than ever before.

CBG works by binding to both CB1 and CB2 cannabinoid receptors in the brain, nervous system, and immune system, providing full-body benefits and protection. Once in your body, CBG helps to increase the production of anandamide. Anandamide is a neurotransmitter that helps with pain regulation, sleep cycles, appetite, and motivation/mood.

Because this cannabinoid is lesser-known and less studied, CBG is more difficult to find in the marketplace. While you may find CBG for sale at a local dispensary, it’s not a common item to find.

Fortunately, Myriam’s Premium Hemp Products online store is always open, and we stock plenty of CBG oils and tinctures. Keep reading to explore more about CBG

Does CBG Make You High?

No! CBG does not make you high. 

CBG is a nonintoxicating cannabinoid, unlike the more popular ones like THC or THCA. Taking CBG does not impact motor function or perception, and is safe to take if you prefer to avoid intoxicants.

CBG for Mental Health

Aside from its many physical benefits, CBG has been shown to improve mental health. Its use has been reported to alleviate a variety of psychiatric symptoms, and respondents in one study even lauded CBG as a more effective treatment plan than their conventional medicinal routine.

CBG & Anxiety

Anxiety is a huge problem in the modern world. We are constantly surrounded by stimulation, and our stress will often morph into anxiety. While there are plenty of treatments available, many of them often cause negative side effects, or just don’t give you the relief you want. Fortunately, CBG is different, and can safely be taken alongside other methods of alleviating anxiety.

Does CBG Work for Anxiety?

CBG has been proven to alleviate symptoms of anxiety, and studies suggest that it does so without the negative effects of many standard pharmaceuticals.

While we don’t know exactly why this is, we do know that CBG promotes muscle relaxation. Paired with its ability to promote dopamine production, CBG mimics the way we naturally deal with anxiety.

Think of it as a massage for your mind. When you’re feeling stressed and anxious, you’ll often find a spot to relax and unwind. When you’re lounging on your sofa, you’re relaxing your muscles. At the same time, your brain is releasing plenty of dopamine, which is responsible for happy thoughts and positive feelings.

CBG for Depression

Thanks to the release of dopamine, CBG also doubles as a potent ward against depression.

Many of the physical effects of CBG are also linked to common causes of depression. One of the most common is chronic pain, which is often relieved by CBG’s anti-inflammatory properties.

For individuals with other ailments, such as AIDS or cancer, CBG is also shown to stimulate appetites. As a result, many users report feeling more energized, as they are naturally encouraged to eat a hearty meal after using CBG.

Where Can I Get CBG?

We’ve already mentioned it, but let’s look a little deeper into the issue of availability. Because CBG is not one of the more popular cannabinoids, it tends to be harder to find.

At Myriam’s Premium Help Products, we always stock high-quality CBG products. We’re also proud to feature two amazing CBG products, and you can easily purchase them directly from us.

CBG 600

Myriam’s Hope Hemp always guarantees that your product will be fantastic, and that’s why we have proprietary blends – we want formulas we can trust. One of these is CBG 600. This mix contains 600 mg of CBG per ounce, which means it packs a real punch! All of our CBG products are full-spectrum, which means you aren’t missing out on any of the essential components of this beneficial cannabinoid. If you are interested in adding additional terpenes to boost flavor and wellness benefits, we can customize any CBG order.

CBG 1200

In addition to our classic CBG 600 tincture, Myriam’s Hope Hemp also offers our NEW CBG 1200 blend. This tincture doubles the amount of active CBG to 1,200 mg per ounce, and it still has the flexibility of our classic CBG 600. Remember, adding additional terpenes can give you a custom blend with added benefits just for your particular needs.

The Myriam’s Hope Hemp Difference

At Myriam’s Hope Hemp, all of our proprietary products are made in the USA. Each tincture, oil, and bottle is rigorously tested to ensure maximum efficacy and absorption. Everything is sugar-free and vegan friendly, which means that everyone can get the all-natural relief that they need.

In addition to our fantastic tinctures, Myriam’s Hope Hemp also offers premium CBD-based topical treatments. If you’re looking for a new way to treat the woes of modern life, then check us out! We’re more than happy to help you find the perfect blend.

What Is CBGA

Reading Time 10 Minutes

The cannabis plant is full of life-enhancing compounds called cannabinoids, and no one knows precisely how many there are; the number may be as high as over 140! We are still discovering more about cannabinoids and their uses every day.

One of these cannabinoids is cannabigerol acid, or CBGA. This non-psychoactive cannabinoid compound has many valuable properties and is one of the few cannabinoids that has received substantial scientific investigation. Here, we cover what you need to know about CBGA and share what we know about this unique compound.

CBGA’s Botanical Function

When a hemp plant starts growing, it only produces one cannabinoid: CBGA. All of the others are derived from this cannabinoid. CBGA is a precursor compound produced in the hemp plant’s trichomes. In the plant, it triggers targeted cell necrosis in the leaves, essentially telling them when to die so that the plant can put more energy towards the flower.

As a precursor compound, CBGA is a foundational compound of the cannabis flower’s other major compounds as a precursor compound. This means that it is at the top of the chain reaction that produces the three major cannabinoid lines: THCA (tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), and CBCA (cannabichromenic acid). These, in turn, become THC, CBD, and CBC. CBGA can also convert to CBG, but in most strains of cannabis, CBGA converts into THC or CBD. This has made CBGA extremely important in hemp research!

Most of what we know about CBGA comes from research on the compounds it turns into. In the 1960s, Israeli researchers isolated CBG; in the 1990s, Japanese researchers discovered that it came from CBGA. Since then, most CBGA research has focused on how to convert it to other cannabinoid compounds. Primarily, this involves synthesizing THCA (and often subsequently THC) for research and pharmaceutical purposes.

The ability to synthesize CBGA is important because it is difficult to keep intact. While CBGA is found in large quantities in young plants, exposure to heat immediately starts the chain reaction that converts it to another molecule. Additionally, most of the CBGA a cannabis plant makes over its life becomes THC or another compound through the plant’s own biological processes.

This has led to advanced research in biosynthesis, and as recently as 2019, researchers discovered how to synthesize CBGA and other cannabinoids in yeast. This means that research on this compound and what it can do will be much easier going forward, as the researchers are not limited to harvesting the minute quantities that the hemp plant naturally produces.

How Does CBGA Work?

CBGA, like all cannabinoids, acts by binding to the body’s endocannabinoid system. This system of receptors is dispersed all throughout the body and only activates in the presence of cannabinoids. When CBGA is converted to CBG, it binds to CB1 receptors that act directly on the brain and nervous system without having a psychoactive effect. CBGA on its own, binds to CB2 receptors, which are involved in the immune system and gastrointestinal system.

What Can CBGA Do For You?

Most of the existing research on CBGA focuses on its transformation to THCA, CBDA, or other cannabinoids. This means that most research on the benefits of CBGA is connected to its use after that transformation. But as we learn more about CBGA, researchers are finding that it has many potential benefits of its own.

COVID-19 Prevention

One of the most recent findings is that CBGA, along with CBDA, may successfully prevent COVID-19 transmission and infection. The cannabinoids prevent infection by binding to the SARS-COV-2 spike protein. This prevents it from entering the cell and reduces the chance of infection. It also shows promise in preventing and treating new variants of COVID-19. While these are preliminary findings and substantial additional research and testing are necessary before truly being considered a treatment for COVID-19, this research is very promising.

Cardiovascular Disease

In vitro studies of CBGA have found that the compound significantly inhibits the enzyme aldose reductase. This enzyme is a major contributor to oxidative stress that leads to heart problems, as well as other negative effects on the body. This research is valuable because synthetic inhibitor drugs have severe negative side effects for many patients. A plant-derived inhibitor drug based on CBGA could help millions of people who suffer from cardiovascular disease or cardiovascular symptoms of metabolic diseases like diabetes.

Inflammation Relief

Rodent studies show that CBGA has a powerful positive effect on some of the metabolic receptors that trigger inflammation. Additionally, CBGA can also inhibit the action of cyclooxygenase enzymes, more commonly known as COX inhibitors. COX inhibitors reduce the production of prostaglandins, which are chemicals that the body produces to help reduce inflammation. By inhibiting the inhibitors, CBGA helps reduce inflammation and pain in the body.

Seizure Treatment

CBGA is a potentially powerful anticonvulsant treatment for seizure disorders like epilepsy. Cannabis has been used to treat epilepsy for thousands of years, and today’s modern hemp-derived epilepsy treatments contain little to no THC. Instead, other cannabinoids are the primary focus. The best known and best understood is CBD, but minor cannabinoids like CBGA show a lot of promise in anticonvulsant research. CBGA has been found to react with numerous seizure-related receptors and is highly effective in certain induced seizure conditions in mice. This could translate into support for an increase in CBGA as a treatment for seizures in humans as well.

Metabolic Disease

CBGA may also help patients with metabolic disorders due to its reaction with peroxisome proliferator-activated receptors (PPARs) that regulate metabolism. When PPARs do not function properly, people accumulate lipids excessively and develop metabolic diseases like diabetes and high levels of cholesterol and triglycerides. One study shows that cannabinoid acids like CBGA are PPAR agonists, which means that they can help regulate PPAR expression. Another study found that cannabinoids positively regulate PPAR-associated genes that control lipid metabolism.

Neuroprotection

In addition to regulating PPAR activity, CBGA also has other regulatory properties. One of these is its ability to protect against the neurodegenerative effects of Huntington’s Disease. In this study, it was found that acidic precursors like CBGA are demonstrably more effective than their
subsequent cannabinoids. This was seen in both cell line studies and rodent studies and is a very promising line of research.

Additionally, CBGA may protect against the neurotoxicity that stems from the stress of oxidation particles, hydrogen peroxide (H2O2), and rotenone, which causes mitochondrial dysfunction. In this in vitro study, a high concentration of CBGA dramatically reduced the rotenone-induced neurotoxicity. CBGA is also shown to prevent the formation of superoxide radicals, which eventually reduces oxidative conditions that lead to neural degeneration. In other words, it’s a powerful antioxidant that can help protect your cognitive function as you age.

Colorectal Cancer Treatment

While it is important to note that the research is in very early stages, CBGA may one day be a vital treatment for patients with colorectal cancer. Colorectal cancer is the third most common cancer and is the fourth leading cause of cancer-related death, so additional therapies and treatments will save many lives. As we mentioned previously, CBGA has cytotoxic or cell-killing effects that tell the plant to redirect energy to the flower instead of the leaves. Its primary job is to tell cells when to die. The effect may not be limited to cells in the hemp plant.

Research shows that these cytotoxic effects also have an effect on colon cancer cells. In experiments on colon cancer cell lines, CBGA killed colon cancer cells, sped up early cancer cell death, and stopped the cancer cell cycle. Additionally, the research is encouraging in regards to preventing the growth and spread of cancerous polyps, which grow into potentially lethal carcinomas.

How To Get CBGA

CBGA is found in all varieties of the hemp plant, including hemp plants that produce low amounts of THC. This means that it’s legal in all 50 states! While CBGA is not mentioned specifically by name in the 2018 Farm Bill or other cannabis laws, it can be derived from hemp plants that contain virtually no THC. Additionally, CBGA is not psychoactive, so it is generally treated with the same considerations as other non-psychoactive cannabinoids. Since CBGA is completely legal, it can be found in a number of locations. Hemp shops and CBD retailers will likely carry CBGA products, as will shops that cater to specialty health concerns and wellness, such as Myriam’s Hemp. Be sure to specify that you are looking for CBGA and not the more commonly-known CBG, as the two have different effects!

How To Take CBGA

If you’re interested in trying CBGA, there are several different ways you can consume it. Remember, CBGA is very susceptible to heat, and as soon as it is exposed to heat, it begins the reaction that changes it into another cannabinoid, typically CBG. That means you probably won’t have much luck consuming it through any leaf-based method, as most of those involve heat.

Even if you keep the temperature low, the drying and curing process itself can also have an effect on the amount of CBGA available to consume. Smoking, vaping, or baking into food will transform your CBGA into CBG, so those routes just are not ideal if you want the full CBGA benefits. And while CBG is helpful in and of itself, it provides different benefits than CBGA!

Tinctures, on the other hand, are a much more reliable way to take CBGA. CBGA can be synthesized in a lab and distilled into a tincture that you can take just like any other cannabinoid tincture. When you choose a CBGA tincture, you should make sure to choose one from a company that is transparent about lab testing and one that uses all-natural ingredients for your safety.

You should also know that cannabinoid precursors, including CBGA, are not present in all types of tinctures. A CBG tincture is not going to contain CBGA. A broad or full spectrum tincture may contain CBGA, along with many other cannabinoids, to enhance the entourage effect.

If you’re looking for specific CBGA responses, however, your best bet is to choose a full spectrum CBGA tincture with a higher concentration of CBGA compared to the other cannabinoids to allow the cannabinoid to shine through. In the coming weeks, we will be releasing our own all-natural CBGA tincture for healthful relief.

Buy CBGA at Myriam’s Hemp

At Myriam’s Hemp, our goal is to share useful information that will help you make the most of your cannabinoid experience. We believe in our products and want to help you take control of your health by offering premium hemp products. We provide hope to those who are suffering from diseases that can have a significantly negative impact on everyday life.

Our cannabinoid products are created with quality at the forefront, and we are constantly striving to enhance our offerings. Our online store features a variety of CBD, CBG, CBN, CBDA, and soon, CBGA products that may provide you with the relief you’re looking for and help you to manage your health without total reliance on traditional pharmaceuticals. Shop Myriam’s Hemp online and order your cannabinoid products today.

References

Can CBDA Help Prevent COVID-19? A New Study Says YES!

Reading Time 4.5 Minutes

Science says yes

It’s common knowledge that CBD from hemp can help lower inflammation and strengthen your immune system overall. A new study done by Oregon State University researchers has found that CBDA, a parent molecule to CBD, may actually help in the prevention of the COVID-19 virus and its variants.

 

How Does Cannabis Help with COVID? What the Study Says

Researchers have already known for a while now what CBDA can do to alleviate inflammation, digestion, and much more (see the last section in this article for more information about that). What an exciting new study at Oregon State University found out recently, however, was what this CBD precursor may be able to do to protect against the virus that produces COVID-19 as well.

A team of scientists at the Linus Pauling Institute at Oregon State University in Corvallis, OR, in partnership with investigators at Oregon Health & Science University in Portland, recently discovered that both CBDA (cannabidiolic acid) and CBGA (cannabigerolic acid) have the ability bind to SARS-COV-2 spike protein. Both of these cannabinoids are found in hemp variations of cannabis.

This is a huge discovery because it means that CBDA and CBGA may have the ability to prevent the spike protein from entering cells and causing COVID-19. The Oregon State University report was published January 10th, 2022 in the Journal of Natural Products. (1)

 

Can CBDA Also Protect Against New COVID Variants?

According to the University of Oregon researchers, the answer could also be yes.

Dr. Richard Van Breeman, principal investigator at the Linus Pauling Institute and professor of chemistry at Oregon State, commented in a recent interview that CBDA and CBGA may be effective against emerging COVID variants as well. Two variants mentioned in the study include “B.1.17” (Alpha variant) and “B.1.351” (Beta variant).

Both Alpha and Beta are currently classified as “VBM” (Variants Being Monitored) by the U.S. Centers for Disease Control. (2) According to Yale University, the Alpha variant was first discovered in the UK in November 2020. Until the emergence of Delta, it was the predominant variant amongst infected individuals in the US.

Also, according to Yale, the Beta variant was discovered in South Africa at the end of 2020. So far it has not been as widespread. Experts state, however, that it is about 50% more contagious than the original virus and potentially 20% more contagious than the Alpha variant. (3)

“Orally bioavailable and with a long history of safe human use, these cannabinoids [CBDA and CBGA], isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2,” the report authors state.

 

More on CBDA

A lot goes into the creation of the cannabinoids most people are familiar with that are found in both medical marijuana and hemp. CBDA and CBGA, which are major players in the formation of CBD, CBG, and CBN are considered “parent molecules”. In other words, those cannabinoids are created first and then CBD and other cannabinoids eventually emerge from them.

 CBDA specifically is considered a powerful healing substance in its own right. That being said, CBDA actually works much differently than CBD and THC cannabinoids in the body. The main difference is that CBDA does not interact much with the endocannabinoid system. It does not bind with CB1 nor CB2 receptors. Instead, it interacts with receptor sites for certain brain and nervous-system precursors such as 5-HT. 5-HT is a chemical needed for the production of serotonin. CBDA also interacts and influences key enzymes to produce its healing effects.

CBDA also affects the production of serotonin itself and the way this hormone interacts in the body. Serotonin is mostly known as a neurologically influential hormone that produces feelings of happiness and fulfillment.

Serotonin does a lot more than this in the body overall, however. It is a key hormonal substance for emotional regulation and the proper functioning of motor skills. It also influences digestion, sleep cycles, and cardiovascular health. According to a 2017 study conducted at the University of Freiburg in Germany, serotonin also plays a part in cytokine and T cell production in the immune system, amongst other things. (4)

Besides being a potential preventative against various strains of COVID, research into CBDA has found that it can also be beneficial for depression symptoms, digestive issues such as nausea and vomiting, brain and nervous system conditions, such as seizures, and for lowering inflammation overall. (5) (6)

 

How Can I Obtain CBDA?

Oregon State University researchers present hopeful research for the possible natural prevention of this dreadful virus that has changed the way the whole world functions. Recent research has found that CBDA in particular is more readily absorbed into the bloodstream and body than regular CBD. What’s more, both CBDA and CBGA are found in hemp. This means that they are legally available in most regions of the US.

You should know, however, that these cannabinoid precursors will not be found in regular CBD products. CBDA, however, can be purchased as super high-quality full-spectrum CBDA oil or as a CBD/CBDA blend right here at Myriam’s Premium Hemp Products!

References:

Results of CBD Liver Safety Study

Study Reports Preliminary Results of CBD Liver Safety

A patient-centered clinical trials company called ValidCare has recently concluded a 7-month study of the effects of CBD use on the liver. Overall, their findings have been advantageous to the consumer as their “investigators report to FDA no evidence of liver toxicity in the 839 adults consuming oral CBD”. This study was in response to the FDA’s request for science-based data to help determine the appropriate regulations for hemp derived CBD products.

The 7 Month Testing Process

With the help of twelve CBD product companies and 839 participants, ValidCare carried out a 7-month study of the effects of CBD on the liver. The study began in August 2020 and came to a close in February 2021. It may seem like conducting a study during the pandemic would prove to be problematic, but the “use of ValidCare’s decentralized clinical research platform and partnership with national laboratories enabled participants and principal investigators to successfully complete this first cohort” and the FDA and brands involved were delivered results within six weeks.

The main purpose of this 7-month study was to “observe any potential liver effects in adults ingesting oral forms of hemp derived CBD for a minimum of 60 days”. To successfully complete this study, ValidCare needed a minimum of 681 participants, and with the help of the participating product companies, they were able to have over 830 participants complete the study.

ValidCare’s Findings

Over the course of the 7-months ValidCare has found “no evidence of liver disease in the 839 participants and no increase in the prevalence of elevated liver function tests when compared to a population with a similar incidence of medical conditions”. Three participants were reported to have three times the normal levels of the liver enzyme ALT, but they were all taking prescription medications that are known to elevate liver enzymes.

The results of the study have been encouraging as it provides sufficient science-based data to the FDA, for them to take action on safety regulations for CBD in the future. That being said, this 7-month study has only been the first cohort, and ValidCare will continue to analyze real-world data and perform a second cohort to add to the statistical certainty for liver safety. ValidCare is “excited for [their] principal investigators to continue, expand and report out on this foundational work in the next few months. Once completed, safety results of this study will be shared with participation brands and the FDA.”

Myriam's Hemp CBD

At Myriam’s Hemp, our goal is to provide valuable information and resources about CBD to consumers and customers alike. In addition, we remain committed to that staying aware of new developments and studies performed within the industry and providing you with resources so you can find the solutions that best work for you.

If you’re looking for high quality CBD products, you can count on Myriam’s Hemp to provide you with reliable CBD tinctures and balms that are free from chemicals and fillers. We only use all natural ingredients and make our products as accessible as possible to consumers by keeping them free of wheat, sugar, and animal products.

Purchase your CBD products from Myriam’s Hemp online today or reach out to a member of our dedicated team to determine which CBD products are right for you!

CBD as Potential Treatment for COVID-19

Recently, a study was conducted by a team of researchers in Illinois at the Rosner Lab at the University of Chicago to analyze if cannabidiol could be a potential treatment for COVID-19. In March 2021 Rosner Lab released their latest findings with evidence demonstrating the inhibiting effect of CBD on the replication of the SARS-CoV-2 virus. This study highlights CBD and its active metabolite as potential preventative agents and therapeutic treatments for SARS-CoV-2 in the early stages of infection.

Why Was This Study Conducted?

With a wide and rapid spread of SARS-CoV-2 across the globe, researchers began to look for alternative ways to reduce the spread and effects of COVID-19. Colleagues at Rosner Lab say that the fact that the virus is still spreading even with the rollout of vaccines highlights the need for alternative approaches. This is especially true for populations with limited access to vaccines.

What Did the Study Involve?

The SARS-CoV-2 virus enters host cells via the binding of a surface viral protein to the human host cell receptor ‘angiotensin-converting enzyme 2 (ACE-2). To test the effect of CBD on SARS-CoV-2 replication, researchers at Rosner Lab pretreated A549 human lung carcinoma cells expressing exogenous human ACE-2 receptors for 2 hours with CBD, before infecting them with SARS-CoV-2. Then after 48 hours had passed, they monitored and analyzed the cells to see if the replication of the SARS-CoV-2 had been inhibited.

The Findings

Overall, the researchers at Rosner Lab have concluded that they have evidence that CBD inhibits the replication of the SARS-CoV-2 virus. In addition to that, they have also released some key findings broken down in simpler terms for the public to understand:

  • After viral entry, CBD acts to block virus replication.
  • CBD has the potential to not only act as an antiviral agent in the early stages of infection but also protect the host against an overactive immune system during the late stages.
  • CBD inhibiting replication of at least one other coronavirus raises the possibility that it may also inhibit other human coronaviruses that could arise in the future.
  • 7-OH-CBD (a metabolite of CBD) is an effective inhibitor of SARS-CoV-2.
  • Analysis of participants taking FDA-approved CBD showed up to ten times a decreased risk of SARS-CoV-2 infection compared to a set of control participants.

Although these findings represent a significant process in the alternative treatment of COVID-19, there are still “several issues that require close examination before CBD can be considered or even explored as a therapeutic for COVID-19”. For example, it appears that the presence of THC may counteract the antiviral efficacy of CBD. And of course, other concerns would need to be addressed, such as the means of administration like smoking or vaping that could potentially cause lung damage. In short, further studies would be needed to determine optimal methods of delivery, and clinical trials should be performed to test the promise of CBD as a therapeutic for SARS-CoV-2.

Myriam's Hemp CBD

We are proud to serve an ever-growing community of families just like ours who keep coming back to Myriam’s Hemp CBD oil and CBG oil for the relief they can count on. We are also committed to providing our customers with quality resources and studies in the industry, so you have all the information needed to find solutions that fit your life.

You can count on Myriam’s Hemp to provide you with high quality CBD products that are free from wheat, sugar, animal products, chemicals, and fillers. Purchase your CBD oil or CBG oil from us today or reach out to someone on our team to determine which products are right for you!

What is the Entourage Effect in CBD?

Many might think that cannabis comprises just two natural ingredients that provide an abundance of health benefits – THC and CBD – but there are various other chemical compounds (phytocannabinoids) that are thought to aid in the delivery of the plant’s natural advantages. These other compounds might not make it onto the webpages of most dispensaries, news agencies, or social media, but as we discover more about the makeup of the cannabis plant, it begs the question: What is the entourage effect? The additional compounds found in cannabis are essential contributors that work together with THC and CBD to provide the effects that many patients and customers seek. This combination of phytocannabinoids that includes CBG, CBC, CBN, and various others has been referred to as the CBD entourage effect, and we believe that it’s important to take a closer look at what that means for you.

What is the Entourage Effect in CBD?

How Does it Work?

The entourage effect occurs as cannabis is smoked or vaporized and the various compounds mix together to provide collaborative benefits. Studies have found that CBD works best when activated by a small amount of THC, and numerous CBD products today contain trace amounts of THC as a result. But while not yet proven, doctors and cannabis experts have developed the theory of the CBD entourage effect based on a combination of research and controlled studies. The research available tells us that combining both terpenes and phytocannabinoids may provide enhanced benefits for the relief of different ailments such as pain, anxiety, inflammation, cancer, epilepsy, and even fungal infections when compared to CBD or THC on their own.

More research is definitely needed, but there is a strong belief that the CBD entourage effect is real, and it could open up a number of doors in terms of alternative healthcare. Many who use cannabis for its known medical benefits prefer flower as opposed to oils and extracts for this reason, as the flower is the most natural and unaltered form of the plant.

Potential Benefits of the Entourage Effect

Knowing what we do about the entourage effect in CBD, it could mean that cannabis is even more beneficial than we ever believed. We would have the ability to pair specific phytocannabinoids together to achieve a particular desired effect, such as for chronic pain relief, anxiety, or even cancer prevention. Again, these are still just theories for the time being, but other benefits could potentially include:

Increased memory function by pairing the pinene terpene with THC

Addiction treatment by pairing CBD with caryophyllene

Reduced anxiety by pairing the terpene limonene with CBD

Advanced sedation by pairing THC with CBN

Currently, there are several cannabis forms available such as oils, tinctures, and other edibles that are labeled as “full spectrum”. This means that they contain pure cannabis oil extracted from plants using advanced technology such as supercritical CO2 extraction machines. These products are intended to contain all of the phytocannabinoids that cannabis offers including THC, CBN, CBD, CBG, terpenes, and hundreds of other compounds that deliver the entourage effect and all of the benefits that go along with it.

When these products are altered to provide customers with different effects, they become labeled as broad-spectrum instead – cannabis products with the THC removed, for example. The advantage of isolating specific compounds, however, is that we can pair intentionally to produce specific effects that can provide medically beneficial results. With further research and development, the possibilities could be virtually endless.

If you’re looking to experience the benefits of the entourage effect in CBD, Myriam’s Hemp is here to help you make an educated choice. We’re committed to providing detailed information surrounding medicinal cannabis as well as the CBD entourage effect in the hope that you can find the relief you need to live a happy, healthy life. Visit our product page to purchase CBD today.

Which Cannabinoid is Right for You?

Cannabinoids are the naturally occurring chemical compounds found in the cannabis plant, many of which are separated to create various products that offer different intended effects. Regardless of what the desired end product is, manufacturers will extract these cannabinoids carefully to preserve their natural benefits so that their full potential can be realized. While there are many different cannabinoids that we know of, some are more well-known than others, such as THC and CBD. Each offers different characteristics and potency levels, and they react with the brain in different ways to achieve specific outcomes.

Which Cannabinoid is Right for You?

What are Differences in Cannabinoids?

While most cannabinoids have demonstrated benefits such as pain relief, they react differently to receptors in the brain. Let’s dive into some of the most common cannabinoids, their effects, and their potential benefits.

THC – Tetrahydrocannabinol. One of the only cannabinoids that will produce a high, THC is also the cannabinoid that is most abundant in marijuana and it has been found to be effective in relieving or reducing pain in some cases, as well as promoting a healthy appetite.

CBD – Cannabidiol. CBD is frequently used for medicinal purposes because it does not produce the same high as THC. However, it can be combined with THC to amplify the effects. Continued use of CBD has demonstrated the potential to improve numerous negative health conditions, such as reduced feelings of stress and better sleep.

CBDA – Cannabidolic Acid. CBDA is the raw acidic form which converts into CBD when it is dried and heated. In its raw acidic form, there have been reports of it potentially being more potent than CBD in smaller doses for anti-inflammatory purposes. This may be useful when used as a remedy for muscle pain or inflammation after an injury or infection.

CBG – Cannabigerol. CBG is becoming more popular among researchers and medical professionals. It has become a choice for alternative cancer fighting strategies as it may decrease the number of bacteria that can grow. If effective, this could stunt tumor and cancer cells.

CBN – Cannabinol. CBN occurs when THC oxidizes and loses its intoxicating effects. This cannabinoid may be able to help with concerns surrounding pain, inflammation, sleep disorders, and appetite stimulation.

Choosing the Right Cannabinoid

Determining the right cannabinoid depends on the ailment that you’re trying to get a handle on. Most cannabinoids have been found to deal with pain symptoms, though CBD has proven to be a popular choice for most people looking to manage regular pain or inflammatory problems such as arthritis. CBD is also readily available in numerous forms and offers a good starting point to begin your healing journey. At Myriam’s Hemp, we carry various options for CBD, CBDA, CBG, and CBN. If you have questions, we’ll happily take the time to help you determine which cannabinoid will offer the right solutions for your individual needs.

Buy Cannabinoid Oil Online at Myriam’s Hemp

All of the products offered at Myriam’s Hemp are made with 100% natural ingredients and are specially formulated for maximum absorption and efficiency. They don’t contain any sugar or wheat and are vegan friendly making them a viable option for most people. Each product contains less than 0.3% THC and focuses instead on the known health benefits of other cannabinoids that can help to promote the relief of a myriad of different medical ailments. Our goal is to show you the change that premium hemp products can exact in your life, and we do that by producing our products with quality at the forefront of our minds. Many of our customers use cannabinoids such as CBD for medical purposes, and you can, too. Shop our available products and purchase CBD or other cannabinoid products online today.

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