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Fearless and Free: How CBD Erases the Lingering Impact of Predator Stress!

Reading Time 11.5 Minutes

People take CBD for lots of different reasons, but one of the most popular is for anxiety or stress relief. According to results from Forbes health survey research, at least 50% of CBD users across all age categories use CBD to relieve stress. 

 

Stress is a very interesting medical phenomenon. We all experience it, and it has significant impacts on all of us. Stress is something that many of us see as just part of everyday life… but stress can have some major medical effects, including heart issues, mental health issues, and immune system problems. Stress impacts every aspect of your health– even your fertility and ability to have kids

 

Finding a way to deal with stress is important, so let’s talk more about stress, why it impacts us, and how CBD research shows a way to deal with stress. Please note that these statements have not been evaluated by the Food and Drug Administration. The products discussed here are not intended to diagnose, treat, cure, or prevent any disease.

Why Does Stress Affect Us So Strongly?

There is a close relationship between stress and health. Stress affects our health strongly due to its impact on various physiological systems in the body. When we experience stress, our body undergoes a series of reactions as part of the “fight or flight” response, which is the body’s way of preparing to deal with perceived threats or challenges. While this response is crucial for survival in the short-term, chronic stress can lead to significant health problems. 

 

Stress triggers the release of hormones such as cortisol and adrenaline. While these hormones are helpful in short bursts, prolonged release due to chronic stress can disrupt the body’s hormonal balance, leading to issues like weight gain, high blood pressure, and compromised immune function. If you experience chronic stress, you may develop a weakened immune system, making the body more susceptible to infections and illnesses. This occurs because stress hormones suppress the effectiveness of the immune system, reducing the body’s ability to fight off pathogens.

 

Stress also contributes to chronic inflammation in the body, which is linked to numerous health problems including cardiovascular disease, diabetes, and autoimmune disorders. Prolonged stress can lead to a persistent state of inflammation, increasing the risk of developing these conditions. Stress can raise blood pressure and heart rate, increasing the risk of heart disease and stroke over time. Chronic stress contributes to the buildup of plaque in arteries, leading to atherosclerosis and other cardiovascular problems.

 

Stress can also affect the digestive system, leading to issues like irritable bowel syndrome, indigestion, and acid reflux. Chronic stress can disrupt the balance of gut bacteria and reduce blood flow to the digestive organs, making these problems worse. 

 

Finally, chronic stress is closely linked to mental health disorders such as anxiety and depression. The constant activation of the stress response can affect neurotransmitter levels in the brain, leading to mood disturbances and cognitive issues. Stress can also interfere with sleep patterns, leading to insomnia or poor-quality sleep. Lack of adequate sleep further exacerbates stress and can contribute to a range of health problems, including impaired cognitive function and increased risk of chronic diseases.

How Do We Study Stress?

It can be challenging to study stress because when we talk about stress in people, there are often a lot of contributing factors. An easy way for researchers to look at stress is by studying a phenomenon called predator stress

 

Predator stress, also known as predatory stress, is a type of psychological stress induced by the presence or threat of a predator. It is a well-established model used in laboratory research to study the physiological and behavioral responses to acute stress in animals. Predator stress is one of the ways that researchers are able to induce stress that can then be used as a proxy for stressful experiences in humans. 

 

The goal of inducing predator stress in research is to understand how animals respond to acute stressors that mimic real-life threats in their natural environment. This stressor triggers a cascade of physiological and behavioral responses, including the release of stress hormones like cortisol or adrenaline, changes in neurotransmitter levels, alterations in brain activity, and changes in behavior such as freezing, fleeing, or defensive behaviors.

 

Studying predator stress in laboratory animals can provide valuable insights into the mechanisms underlying stress responses and how they impact various physiological systems in humans, including the nervous, endocrine, and immune systems. This research can have implications for understanding stress-related disorders in humans and developing potential interventions or treatments to mitigate the negative effects of stress on health and well-being.

How Does CBD Impact Predator Stress?

In a recent study, neuroscientists looked at the impact of CBD on predator stress in rats. Specifically, they wanted to understand the potential impacts of CBD for PTSD-related symptoms, which can be modeled with long-term predator exposure.

 

Posttraumatic stress disorder (PTSD) is a serious condition that can develop after a traumatic event. Exposure to predators can cause lasting anxiety in rodents, similar to symptoms seen in people with PTSD. Cannabidiol (CBD), a non-psychoactive compound found in cannabis plants, is frequently used for stress relief, so the researchers wanted to understand how it might be able to help the rats. In this study, researchers gave male rats CBD after they were exposed to a cat– the predator in the predator stress question. Some rats received a single dose of CBD, while others received repeated doses. A week later, the rats were tested in a maze to measure their anxiety levels. 

 

The researchers also looked at how CBD affects specific brain receptors called 5HT1A receptors, which are involved in anxiety. They found that repeated doses of CBD prevented the long-lasting anxiety caused by the predator exposure, implying that it might be feasible to use CBD for PTSD treatment, possibly by affecting these specific brain receptors.

Why Use Predator Stress?

Exposure to predators like cats can lead to immediate defensive behavior and long-lasting changes in behavior in rodents. These changes are more significant compared to models using other stressors like electric shocks. The exact brain mechanisms behind these lasting effects are still unknown, but they might involve changes in certain brain structures and neurotransmitter systems related to fear and memory.

What The Study Found

In the study, the researchers found that giving rats repeated doses of CBD after they were exposed to a predator helped prevent long-lasting anxiety caused by the traumatic event. However, after the predator exposure, the rats also showed reduced activity in certain parts of a maze, which could suggest a decrease in general activity rather than just anxiety. This reduction in activity is common in studies using anxiety-inducing drugs or procedures. The researchers believe it might be because these drugs or procedures make rats more alert to potential threats in the maze.

 

 Previous studies have shown that CBD can reduce anxiety in rodents and humans. It’s thought to work by affecting brain activity related to emotions. Unlike previous studies where CBD was given shortly before testing, the researchers started giving CBD to the rats one hour after the predator exposure and ended it 24 hours before testing. This suggests that CBD might not only have immediate effects on anxiety but also affect long-term changes caused by stress.

 

Overall, the researchers’ study suggests that repeated doses of CBD can help prevent long-lasting anxiety caused by exposure to predators in rats. CBD might work by affecting serotonin receptors in the brain, but its exact mechanisms of action are still unclear. More research is needed to fully understand how people can use CBD for PTSD and other stress-related disorders.

 

Using CBD for Stress

If you want to try CBD for your own stress, you want to make sure that the product you use is as safe and effective as possible. Full-spectrum CBD allows you to take advantage of the entourage effect without the psychoactive effects of many other cannabinoids. You should always choose lab-tested CBD for your safety! Many people find that a tincture is the easiest, most effective way for them to take CBD. 


At Myriam’s Hemp, we believe that everybody should have the information they need to take charge of their own wellness. Stress impacts everybody, and more and more people are turning to natural remedies like CBD to help manage the long-term effects. If you’re interested in trying CBD for yourself, don’t hesitate to reach out– we’d love to hear from you!

References

Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors 

Impacts of stress on reproductive and social behaviors 

Inflammation: The Common Pathway of Stress-Related Diseases 

Mind‐Body Medicine: Stress and Its Impact on Overall Health and Longevity 

Physiology of Sleep–Interactions between stress and sleep: from basic research to clinical situations 

Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry 

Predator Stress – an overview 

Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options 

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

CBD for Pets: Pain & Anxiety

Reading Time 5 Minutes

Nobody likes seeing their pets struggling. Pet owners do everything they can to keep their companion animals happy and healthy, and that means attending to both their physical and mental health. We take our pets to the vet to ensure that they aren’t injured or sick, but the field of animal mental health is much newer than general veterinary care. Today, the market is flooded with products for pet anxiety. This includes CBD products. But do these products actually work? 

 

Until recently, there was little formal scientific research on the safety and efficacy of CBD’s use in companion animals. But like many other aspects of hemp-related research, this field of research is expanding.

CBD for Dogs’ Anxiety

Animals can suffer from anxiety, just like people. In fact, canine anxiety is on the rise as people who got pandemic pets return to the office. There are many products designed to help with your pets’ anxiety, including physical devices like the Thundershirt and anti-anxiety products like CBD for pets. But is CBD good for anxiety in dogs? Does it actually work? Findings in a literature review of the current state of pet CBD research suggest that it does!

 

One study found that a single dose of CBD was sufficient to reduce stress and anxiety in dogs during car travel and during separation from their people. Dogs were given either a placebo or CBD capsule and, two hours after administration, were taken for a car ride or separated from their humans. Researchers found that dogs treated with CBD had significantly lower stress hormone (cortisol) levels, whined less, and were calmer than the dogs that received a placebo.

 

Another study that looks at aggression in shelter dogs, who live in a high-stress environment and don’t have the same regular interaction with people that dogs in pet homes do, found that CBD use reduced aggressive behavior and kept the dogs calmer. Not only is this good for the dogs’ mental well-being, it may also help them find homes faster. It’s a win for everybody!

CBD for Dogs’ Pain

Arthritis is a very common problem for dogs as they age– just like it is with people. And just like how many people take CBD for their arthritis pain, pet owners are turning to CBD for their senior pets’ arthritis. One study that looked at pet supplements for arthritis pain found that CBD offered more high-quality results than many other types of supplements. Additionally, a case study from Cornell’s veterinary school found that a low dose– 2 mg of CBD per kilogram of pet bodyweight– helps increase comfort and activity in dogs with arthritis

CBD for Cats

While research shows that dogs can tolerate CBD doses safely, veterinary researchers still aren’t sure about cats. A study that looked at cats’ tolerance of CBD found that cats do appear to absorb CBD differently than dogs, showing lower serum concentrations and adverse effects of excessive licking and head-shaking during oral CBD oil administration. (However, any cat owner knows that this is fairly normal behavior for many cats when given medication.)

 

Another cat safety study found that adverse effects in cats given both CBD and a CBD/THC mixture were linked to the carrier oil, and that most of the adverse events were gastrointestinal in nature. There were no clinically significant changes in complete blood counts or clinical chemistry across treatment groups, indicating overall safety and tolerance. But cats dosed with THC in addition to CBD experienced more adverse events than the cats who were just given CBD– suggesting that CBD alone may be safer.

Cannabis Toxicity in Cats and Dogs

If you’ve done any research into cannabinoids for domestic pets, you may have come across reports of toxicity in these animals. According to the American Veterinary Medical Association, this is most frequently the result of the animal eating an edible that contains THC and is often related to the non-THC ingredients, like chocolate, oils, and sugar substitutes. It may also be linked to the high, human-grade doses in these products. 

 

There have been pet deaths related to cannabis toxicity, but these have typically come from accidental ingestion– not supervised care. If you want to administer CBD to your pet, make sure that you’re giving them an appropriate dose. The good news is that safety data shows that CBD is well-tolerated in dogs, although there is insufficient information on the safety profile of CBD in cats. 

Exotic Pets and CBD

There are very limited formal studies supporting the use of CBD in animals. However, that doesn’t mean that it doesn’t work– plenty of veterinarians have noted that CBD can have beneficial effects for dogs and cats. This is supported by the research that exists. But non-mammal pets do not metabolize cannabinoids the same way that mammals do. Birds in particular are extremely sensitive, so CBD is likely not a good choice for them. There is also very limited information on CBD and its effect on reptiles. There is one instance of CBD being used to successfully treat a fatty tumor in a snake, but there are no formal inquiries into the subject.

Dosing CBD for Cats and Dogs

In a 2020 study by the Waltham Petcare Science Institute, cannabinoid researchers worked to establish a healthy baseline dose of CBD for cats and dogs. They found that a dose of about 4mg of CBD per kilogram of the animal’s bodyweight was sufficient to see results without causing adverse effects. 

 

If you want to try CBD for your beloved pet, our high-quality, full-spectrum Pet CBD Oil is a great choice. However, if your pet needs a higher dose (especially if they’re a larger dog), our human-grade tinctures like our CBG, CBDA, and higher potency CBDs (Daily 25, Daily 50) are perfectly safe for pets, too. However, if you want to use one of these tinctures, choose the vanilla carrier oil option. Animals are more sensitive to olive oil, and it can cause stomach upset and diarrhea.

 

At Myriam’s Hemp, we know how much you care for your whole family– furry family members included. Contact us today if you have any questions about how to start treating your pet’s anxiety or pain with CBD!

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

CBD & Recovery: A Fitness Game-Changer

Reading Time 6 Minutes

Whether you’re a fitness buff or new to the exercise game, post-workout recovery is an important part of your fitness journey. The pursuit of new and better recovery strategies has led many individuals to explore alternative approaches, and one such avenue gaining attention is the use of CBD. As fitness enthusiasts increasingly seek natural and holistic methods to enhance recovery, the role of CBD in mitigating exercise-induced fatigue, muscle soreness, and promoting overall well-being has become a subject of curiosity. In this exploration, we delve into the emerging research surrounding CBD’s potential benefits for workout recovery.

What Is Workout Recovery?

Before talking about CBD for muscle recovery, let’s take a look at the recovery process as a whole. Workout recovery is an integral and often underestimated component of any effective fitness regimen. After engaging in physical exercise, the body undergoes stress and fatigue, causing microscopic damage to muscle fibers and depleting energy stores. Proper recovery is crucial to allow the body to repair and adapt, leading to increased strength, endurance, and overall fitness. 

 

One key aspect of recovery is rest, which allows the body to divert energy towards repairing tissues and replenishing glycogen stores. Quality sleep is particularly vital during this phase, as it promotes the release of growth hormones and facilitates the repair of damaged cells. Additionally, hydration plays a pivotal role in recovery by replenishing lost fluids and aiding in nutrient transport to cells, promoting optimal physiological function. Nutrition is another fundamental element of effective workout recovery. Including anti-inflammatory foods rich in antioxidants, such as fruits and vegetables, can also aid in reducing inflammation and supporting the body’s natural healing processes. 

 

Incorporating recovery strategies into a fitness routine not only accelerates recovery but also helps prevent burnout, enhances performance, and contributes to the overall well-being of individuals committed to their fitness journey.

Can CBD Help With Recovery?

CBD, or cannabidiol, is a compound derived from the cannabis plant that has gained popularity for its potential therapeutic benefits, including its role in workout recovery. While research on CBD is still in its early stages, some studies and anecdotal evidence suggest several ways in which CBD may contribute to improved recovery after exercise:

 

Anti-Inflammatory Properties: CBD is known for its anti-inflammatory effects. Intense workouts can lead to inflammation and muscle soreness. CBD may help mitigate inflammation by interacting with the endocannabinoid system, potentially reducing pain and promoting faster recovery.

 

Pain Relief: CBD may act as a natural analgesic, and some people find that it possibly helps to alleviate pain associated with muscle soreness and exercise-related injuries. This can be particularly beneficial for athletes or individuals engaged in high-intensity training.

 

Stress and Relaxation: Regular exercise can be physically demanding and may induce stress on the body. CBD has been studied for its potential to reduce stress and improve relaxation, which could contribute to an overall sense of well-being during recovery periods.

 

Improved Sleep Quality: Quality sleep is crucial for effective recovery. CBD has been reported by some users to have a calming effect that promotes better sleep. By supporting a restful night’s sleep, CBD may enhance the body’s natural recovery processes.

 

Muscle Relaxation: CBD may have muscle-relaxant properties, potentially aiding in the relaxation of tense muscles. This could be particularly beneficial for individuals dealing with muscle spasms or tightness after intense workouts.

 

However, while all of these properties could contribute to improved post-exercise recovery, only recently has research directly addressed the potential benefits of cannabinoid use during recovery. Currently, two major studies have explored this potential use of CBD for muscle recovery: one published in 2021, and one that came out recently in 2023.

 

The original investigation of CBD for recovery was primarily a literature review. It examined available evidence indicating that CBD might have the potential to be included in recovery strategies for addressing fatigue and muscle damage resulting from both physical and cognitive efforts in physical activity. The review article pointed out that our understanding of how CBD influences the body during physical activity is not complete, leaving notable gaps in knowledge.

 

The more recent 2023 study on cannabis for recovery aimed to change that. Let’s take a closer look at its findings!

THC and CBD for Muscle Recovery

This study looked at both CBD and THC together for muscle recovery. CBD and THC, found in cannabis, could potentially aid in recovering from both aerobic and resistance exercise. Some studies show that cannabis users, including athletes, use these compounds to assist with exercise recovery, alleviate muscle soreness, reduce inflammation, and enhance sleep. Survey data also suggests that cannabis users feel that THC and CBD contribute to relaxation and well-being with minimal perceived negative effects.

 

While various recovery methods like stretching, heat therapy, foam rolling, and others are known to enhance exercise recovery, there is limited research on the direct impact of cannabis, CBD, or THC on muscle soreness and recovery after aerobic or resistance exercise. This study aims to investigate whether individuals who regularly use cannabis and engage in exercise perceive benefits in terms of recovery. The hypothesis was that regular cannabis users would report positive effects on recovery from both aerobic and resistance exercise, attributing motives such as pain management, anxiety reduction, and improved sleep to their cannabis use.

 

The Findings

The study surveyed cannabinoid users who regularly exercise about their recovery techniques. The responses demonstrated that a significant portion of participants, around 20% for CBD and 61% for THC, reported using cannabis products to aid in recovery after both aerobic and resistance exercises. When asked about the effectiveness, the majority believed that both CBD and THC contributed positively to their recovery, with 93% affirming CBD and 87% affirming THC. 

 

Results indicated that a significant number of participants use CBD and/or THC to aid recovery from both aerobic and resistance exercise. Interestingly, men using CBD reported higher exercise intensity than those using THC, and a similar pattern was observed for women in aerobic activity. Despite limited conclusive data on cannabis and exercise recovery, the study revealed that a majority of participants believed CBD and THC positively influenced their recovery. 

 

Reasons for using CBD and THC included pain management, inflammation reduction, and improved sleep, aligning with the proposed roles of these substances in recovery. The study also highlighted that cannabis users often combine these products with traditional recovery methods, such as stretching and supplements. However, the study had limitations, including its small sample size and reliance on self-reported data, and further research is needed to better understand the relationship between cannabis use and exercise recovery.

Taking CBD For Recovery

If you want to try CBD for recovery, the easiest way to take it is by using a tincture made with lab-tested, high-quality CBD. Tinctures are easy to dose, and the doses are easy to customize. All of our tinctures at Myriam’s Hope are made with all-natural, lab-tested full-spectrum CBD, using only organic carrier oils. We know that you have a lot of options when it comes to your wellness, and we want everybody to have access to the information they need to make their own decisions about their well-being. Contact us today with any questions you may have!

References

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

What To Do When CBD Stops Working

Reading Time 5 Minutes

cbd oil

Dosing CBD can be as much an art as it is a science. While there are recommendations for starting doses, everybody’s tolerance of and reception to cannabinoids is variable. Today, we’re going to discuss what to do when CBD stops working. The answer isn’t always to increase the dosage! Sometimes, in order to return to the effectiveness of your CBD, you need to take a CBD tolerance break.  

Why Is My CBD Not Working?

First, if your CBD stopped working, it might not be time for a tolerance break. Before we go into the science of why you may need a break sometimes, it’s important to address other reasons that your CBD stopped working. 

Dosage

Your unique body chemistry may simply require a higher dose. One of the most common reasons for CBD not working is that you might not be taking the right dosage. Everyone’s body reacts differently to CBD, and what works for one person may not work for another. You might be taking too little to experience noticeable effects or too much, which could lead to tolerance or unwanted side effects. It’s often recommended to start with a low dose and gradually increase it until you find the right amount that works for your specific needs.

Quality 

The quality of the CBD product you’re using can significantly impact its effectiveness. Ensure that you’re purchasing CBD from a reputable source that provides high-quality, lab-tested products. Low-quality or contaminated products may not contain the amount of CBD stated on the label. Lab-tested CBD in pure carrier oil is best– check the label for batch information and links to test results.

Product Type

There are various forms of CBD products available, including oils, capsules, edibles, topicals, and more. The method of consumption can affect how your body absorbs and utilizes CBD. If one type of product isn’t working for you, consider trying a different one to see if it produces better results.

Tolerance

If you’ve been using CBD regularly for an extended period, you may have built up a tolerance to it. In such cases, taking a tolerance break might be necessary to reset your body’s sensitivity to CBD.

 

What Is A CBD Tolerance Break?

If you’ve been on a normal dose of CBD for a long period of time, you may need a tolerance break. A tolerance break, often referred to as a “T-break,” is a period of time during which an individual refrains from using a cannabinoid like CBD to reduce their body’s tolerance to the substance. Tolerance can develop when the body becomes accustomed to the presence of a substance, requiring larger amounts to achieve the same desired effects. Tolerance breaks are commonly associated with cannabis and THC, but can also refer to other cannabinoids, including CBD.

 

The primary goal of a tolerance break for CBD is to reset your body’s sensitivity to the compound. By taking a break from CBD, you allow your endocannabinoid system to return to its baseline, making it more receptive to the effects of CBD when you resume its use. This can help you achieve the desired effects with smaller doses.

How Long Should a CBD Tolerance Break Last?

The duration of a tolerance break can vary from person to person, depending on factors such as the frequency and dosage of CBD use. A common recommendation is to take a break of at least one to two weeks, although some individuals may choose to extend it to a month or longer for a more significant reset. The ideal length of your break should be determined based on your specific needs and how quickly you want to reduce tolerance.

 

While there isn’t an exact definition for how long a tolerance break can last, there is one study that shows that cannabinoid receptors began to return to normal after about 48 hours. However, this study was only done with men who use THC on a daily basis, so this may vary based on your body chemistry, other medications, and how frequently you use CBD. 

What to Expect During a CBD Tolerance Break

During a tolerance break, you might initially experience some discomfort if you’ve been using CBD for its therapeutic effects. This discomfort could include a return of symptoms you were treating with CBD. However, as your tolerance resets, you should notice that you require less CBD to achieve the same benefits when you resume using it.

Why Does A CBD Tolerance Break Work?

A CBD tolerance break works by allowing your body’s endocannabinoid system to reset and regain sensitivity to CBD. Tolerance to cannabinoids develops when your body becomes accustomed to their presence, leading to reduced effects and requiring higher doses to achieve the same results. Taking a break from CBD can reverse this tolerance for several reasons.

Receptor Sensitivity

The endocannabinoid system in your body consists of cannabinoid receptors, including CB1 and CB2 receptors. When you use CBD regularly, these receptors can become less responsive to the compound. 

Downregulation

Regular use CBD can lead to a downregulation of cannabinoid receptors, meaning there are fewer receptors available for CBD to bind to. During a tolerance break, the number of receptors may increase as your body recognizes a reduced presence of CBD, making it more responsive to the compound when you reintroduce it.

Neuroadaptation

Long-term use of CBD can lead to neuroadaptation, where your brain adjusts its functions to accommodate the consistent presence of the compound. Taking a break allows your brain to return to a more balanced state, potentially making CBD more effective when you resume its use.

Reduced Metabolism

With regular CBD use, your body can become more efficient at metabolizing and eliminating the compound. A tolerance break gives your body a chance to clear CBD from your system, so when you reintroduce it, you experience its effects more strongly.

Reintroducing CBD After a Tolerance Break

When you decide to resume CBD use after a tolerance break, start with a lower dosage than what you were previously using. Gradually increase the dosage until you find the minimum effective amount needed to achieve the desired effects. This cautious approach can help you avoid overshooting and building up tolerance too quickly.

 

When you reintroduce CBD after your tolerance break, it’s important to use high-quality CBD in small doses and work your way up. At Myriam’s Hemp, we pride ourselves on our top-grade, lab-tested CBD. Contact us today with any questions you have about hemp-based pain relief options or to find out which of our CBD products is best for you!

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

CBD as a Potential Solution for Severe Tamoxifen Side Effects

Reading Time 10.6 Minutes

Young female doctor meeting with older couple
Image by Unsplash+ in collaboration with Getty Images

One of the many reasons that cancer patients turn to CBD is side effect management. Cancer treatment involves a lot of complex medications, and these medications often have severe side effects. One of these drugs is Tamoxifen, which is commonly used in breast cancer treatment. 

 

Unfortunately, Tamoxifen has a great number of side effects. But the good news is that there is promising research that shows that CBD may help with these side effects. Let’s take a look at what Tamofixen is, who takes it, and CBD’s potential to relieve its side effects.

What is Tamoxifen?

Many cancer patients, especially breast cancer patients, are familiar with the drug Tamoxifen. Also known as Nolvadex® or Soltamox®, Tamoxifen plays a crucial role in their treatment journey by targeting hormone-sensitive tumors and helping to prevent the growth of cancer cells stimulated by estrogen.

 

Tamoxifen is commonly prescribed as a part of cancer-treating hormone therapy. It is not a chemotherapy drug, and is only prescribed when tumors respond to your natural growth hormones. Tamoxifen belongs to a class of drugs known as selective estrogen receptor modulators (SERMs). It is commonly used in the treatment of hormone receptor-positive breast cancer, which is a type of breast cancer that grows in response to the presence of estrogen. Tamoxifen works by blocking the effects of estrogen in breast tissue, thereby slowing down or inhibiting the growth of hormone-sensitive tumors.

Who Takes Tamoxifen?

As one of the most commonly prescribed drugs in cancer-treating hormone therapy, Tamoxifen is typically prescribed to patients in several categories.

Breast Cancer Patients

Tamoxifen is commonly prescribed to both premenopausal and postmenopausal women with hormone receptor-positive breast cancer. It may also be prescribed to men with breast cancer.

High-Risk Individuals

In some cases, individuals with a strong family history of breast cancer or other risk factors may be prescribed Tamoxifen to reduce their risk of developing breast cancer in the future. This is known as chemoprevention.

Post-Surgical Patients

Tamoxifen is sometimes prescribed after surgery to reduce the risk of invasive breast cancer in women who have been diagnosed with hormone receptor-positive DCIS.

Tamoxifen Side Effects

Like other anti-cancer medications, Tamoxifen has many known side effects. These can vary in intensity and are different from person to person. However, Tamoxifen patients can expect to possibly experience the following: 

 

    • Hot Flashes: Tamoxifen can cause sudden and intense feelings of warmth and sweating, often accompanied by flushing of the face and neck.
    • Menstrual Irregularities: For premenopausal women, Tamoxifen can cause changes in menstrual cycles, including irregular periods or even cessation of periods.
    • Vaginal Discharge and Dryness: Some women may experience changes in vaginal discharge and dryness, which can cause discomfort during sexual activity.
    • Mood Changes: Tamoxifen might cause mood swings, depression, or anxiety in some individuals.
    • Blood Clots: There is an increased risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism.
    • Endometrial Cancer Risk: There is a small increased risk of developing endometrial (uterine) cancer with long-term use of Tamoxifen.
    • Bone Health: Tamoxifen can affect bone health and may increase the risk of osteoporosis in postmenopausal women.
  • Nausea: Tamoxifen can affect your appetite and ability to keep food down.
  • Fatigue and Headaches: Some people report feeling tired and drained while on Tamoxifen, and headaches are commonly reported.
  • Edema: Tamoxifen can often cause fluid retention and swelling in the legs.


Tamoxifen is a highly effective treatment, but the side effects can be uncomfortable, even painful. Recent studies have looked to CBD as a potential treatment for the side effects of Tamoxifen. 

CBD as a Treatment for Tamoxifen Side Effects

Treatments derived from cannabis have long been used by cancer patients to help manage symptoms such as pain, nausea, and loss of appetite, often as a complementary approach alongside conventional medical treatments. Many cancer patients have turned to CBD oil because they believe it might provide relief from various side effects of cancer treatments, such as pain, nausea, anxiety, and sleep disturbances. 

 

However, it’s important to note that while many individuals report positive experiences, scientific research on the effectiveness and safety of CBD oil for cancer-related symptoms is still ongoing, and individual responses can vary. With the recent legalization of industrial hemp and hemp-derived products, cannabinoid research is flourishing both in the US and internationally. Notably, a recent study explored the interaction between Tamoxifen and CBD, marking a significant step in this growing field of research.

 

People who are looking for relief from the side effects of Tamoxifen are turning to substances like CBD oil, which comes from the cannabis plant. However, there’s a concern that CBD oil might change how Tamoxifen works in the body. CBD can influence hormone production, and as Tamoxifen works by blocking that hormone production, there’s a possibility that the interaction between CBD oil and Tamoxifen could alter the intended effects of the medication, potentially affecting its ability to effectively treat hormone receptor-positive breast cancer. 

 

This study had two main goals:

  • Determine how CBD oil affects the way Tamoxifen behaves in the body.
  • Discover if using CBD oil can actually help with the side effects of Tamoxifen.

 

The study involved patients who were already taking Tamoxifen and had a certain level of a substance called endoxifen in their bodies. This substance is related to how Tamoxifen works. The researchers took samples from these patients to see how the levels of endoxifen changed when they started using CBD oil. They also asked the patients about the side effects they were experiencing and how those changed after using CBD oil.

 

The researchers found that when patients used CBD oil, the levels of endoxifen in their bodies went down by about 12.6%. However this decrease was still considered acceptable based on the standards used for comparing medicines.

 

When it came to the side effects, the researchers used a questionnaire called FACT-ES to measure how patients were feeling. They discovered that the part of the questionnaire that looked at hormone-related symptoms improved by about 6.7 points, and the patient’s overall quality of life improved by about 4.7 points when they used CBD oil.

 

In conclusion, the researchers found that using CBD oil alongside Tamoxifen might be okay if the CBD oil is good quality and the dose is 50 mg or less. It doesn’t seem to substantially interfere with how Tamoxifen works, and it might actually help with some of the side effects. This information could be useful for patients and doctors who are considering using CBD oil to manage the effects of Tamoxifen.

 

It is vital for patients prescribed Tamoxifen to continue taking it. However, an investigation into patient adherence to Tamoxifen shows that at least 31% of patients who take it stop before the full course of medication is completed. If CBD can help manage side effects and thereby encourage patients to keep up with their prescriptions, it may improve breast cancer outcomes. People have been taking CBD for breast cancer informally for decades; now, with more research, we are developing a clearer understanding of just how much it can help.

 

Taking CBD for Tamoxifen Side Effects

If you want to take CBD for cancer medication side effects, like those experienced with Tamoxifen, there are a few guidelines you should follow. First, the study notes that a dose of 50 mg or less is acceptable when taking Tamoxifen. Our Daily 50 CBD tincture makes it easy to measure out the proper amount. However, we highly recommend consulting with a licensed medical professional with experience in dosing cannabis for medical conditions.

 

Secondly, the study notes that the CBD oil should be high quality. While CBD is currently not regulated by the Food & Drug Administration, and these products are not intended to diagnose, treat, cure, or prevent any disease, lab-tested cannabinoids are the best way to ensure your safety. You can rest easy knowing that our tinctures are free from impurities and inclusions.

At Myriam’s Hemp, we want everybody to have access to the information they need to make health decisions, especially when managing the devastating effects of cancer. We know that you have many options for relief, and we believe that you deserve to explore them fully. Contact us today if you have any questions about our premium cannabinoid products.

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

CBN: The Ultimate Sleep Hack

Reading Time 5 Minutes

Comfortable sleeping with CBD

Did you know that nearly 70 million Americans have some kind of sleep disorder? Sleep is integral to good health and wellness, but many of us aren’t getting enough of it– or even if we are getting enough sleep, it isn’t good sleep. And that’s a problem. Sleep is important for so many aspects of our wellness, including: 

  • Cognitive function
  • Memory consolidation
  • Problem-solving skills
  • Immune system function
  • Growth and healing
  • Mood regulation
  • Stress management
  • Emotional resilience
  • Muscle recovery and repair
  • Appetite regulation
  • Metabolic health
  • Heart health
  • Hormone regulation

 

The bottom line is that sleep impacts nearly every aspect of our lives, and getting sufficient good sleep is absolutely essential. But if you’re one of the 1 in 4 adults who develops insomnia each year, how can you improve your ability to get good quality sleep?

 

This is where hemp for sleep may be able to help. Drowsiness is a well-known effect of several cannabinoids, which means that many have the potential to help you get to sleep. However, one cannabinoid in particular, CBN, has demonstrated some critical positive effects on sleep in lab tests.

What Is CBN?

Cannabinol, commonly known as CBN, is a cannabinoid found in the cannabis plant. Typically it exists in trace amounts and is most frequently found in older plants. Unlike its more well-known counterpart, THC (tetrahydrocannabinol), CBN is not known for its psychoactive properties. Instead, it is often associated with potential sedative effects. CBN is believed to be a byproduct of the degradation of THC through exposure to heat and oxygen, and it has gained attention for its potential role in promoting relaxation and aiding sleep. 

 

While research on CBN is still in its early stages, studies suggest it interacts with the endocannabinoid system, influencing various physiological functions. As interest in cannabinoids continues to grow, CBN is becoming a subject of exploration for its potential therapeutic applications, although more research is needed to fully understand its mechanisms and benefits.

 

Currently, there are a handful of studies looking at the relationship between CBN and sleep. Let’s dive deeper into the most recent one that shows how CBN can impact your ability to get the sleep you need.

The Study

Recently, a major international study about the impact of CBN for sleep was completed. This study aimed to explore the impact of CBN alone and in combination with cannabidiol (CBD) on sleep quality. This was the first study of its kind for CBN and sleep, expanding on previous research that was mostly focused on basic behavioral findings and preclinical toxicology. 

 

The research was conducted as a double-blind, randomized, and placebo-controlled study from May to November 2022. Participants, aged 18–55, reporting “very poor” or “poor” sleep quality were randomly assigned to receive a placebo, 20 mg CBN, or various combinations of CBN and CBD for seven consecutive nights. The primary focus was on sleep quality, while secondary measures included factors like sleep onset latency, awakenings, wake after sleep onset (WASO), overall sleep disturbance, and daytime fatigue. 

 

Four previous studies have also examined the impacts of CBN on sleep. However, three of them tested proprietary formulations, and only one was placebo-controlled. This means that while these studies showed interesting results, they weren’t as thorough and didn’t have the same type of rigor that the new placebo-controlled study does. Placebo controls enhance the rigor and validity of clinical trials, providing a robust foundation for drawing accurate conclusions about the real impact of a given intervention.

 

The study did have some limitations. The authors noted that these include the need for future research on different CBN doses, achieving a larger size, exploring both subjective and objective sleep measures, and studying the potential effects of stopping regular CBN use. Despite these limitations, the study contributes valuable insights for both the use of cannabinoids for wellness, as well as pharmaceutical development to address common and challenging sleep problems.

The Findings

The findings revealed that of the treatment troops, the group that received 20 mg CBN alone demonstrated potential improvement in sleep quality. They experienced significantly reduced awakenings and overall sleep disturbance compared to the placebo. Importantly, adding CBD did not enhance the positive effects of CBN. (We’ll talk more about that soon.) The study suggests that taking 20 mg of CBN nightly might be beneficial in improving overall sleep disturbance without causing daytime fatigue. This research sheds light on the potential use of CBN for sleep, presenting an alternative to existing treatments that often come with side effects and adherence challenges.

Is CBD or CBN Better For Sleep?

Numerous people take CBD for sleep. However the study suggests that CBN might be the better option. In the study, a 20 mg dose of CBN was found to decrease the number of awakenings and the overall disturbance during sleep. However, formulations containing CBD did not show any improvements in sleep outcomes. Surprisingly, despite the common combination of CBD and CBN in various products, including a pharmaceutical named ZTL-101, it was unexpected to find that CBD not only failed to enhance the effectiveness of CBN on sleep but might even diminish its positive effects. This finding aligns with a previous study showing CBD causing sleep issues when combined with THC. Ultimately, it suggests that CBD could counteract the sleep benefits of other cannabinoids when used together. 

Taking CBN For Sleep

Overall, the study (and prior research) demonstrate that CBN has the potential for positive effects on your overall wellness due to improved sleep. If this is something you’d like to try for your own well-being, there are several ways to take CBN. The most effective for many people is taking it as a tincture oil, which allows you to have control over your dose. This means that if the 20 mg dose from the study doesn’t work for you, you can easily scale up or down by adjusting how much of the oil you take. Our CBN tincture oil is made in-house and contains natural ingredients that are lab-tested for quality assurance. 

 

At Myriam’s Hope, we love helping people take charge of their well-being. Our premium hemp products are formulated to help you with relaxation, stress, and other wellness challenges. We know that you have lots of options and that wellness claims can be very confusing– that’s why we do our best to share the most recent scientific developments and make that information accessible to you. Don’t hesitate to reach out to us with any questions you may have about CBN, CBD, or any of our other cannabinoid products!

 

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

Should Oncologists Trust Cannabinoids?

Reading Time 9.7 Minutes

Should Oncologists Trust Cannabinoids?

People have been using cannabinoids for thousands of years. The oldest known use comes from China, around 2800 BC, when it was listed in Shen Nung’s pharmacopeia, or book of medicinal drugs and their applications. Cannabis was used therapeutically in the medical texts of the Hindu, Assyrian, Greek, and Roman civilizations. These ancient medical texts reported cannabis to help people deal with numerous health problems, including arthritis, depression, amenorrhea, inflammation, pain, lack of appetite, and asthma.

 

However, in the world of modern medicine, cannabis’s status as a helpful medical plant has largely been repressed due to the plant’s status as a controlled substance in the United States and abroad. This has led to a market of secondary importance, as cannabinoids have been relegated to the classification of alternative medicine. 

 

And for many doctors, that’s a big problem. There are only a few FDA-approved medications derived from cannabis, including: 

  • Epidiolex, which contains a purified form of CBD derived from cannabis, is approved for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome, two rare and severe forms of epilepsy.
  • Marinol and Syndros, which contain dronabinol (synthetic THC), are approved for nausea and vomiting caused by cancer chemotherapy. Dronabinol is also used to treat loss of appetite and weight loss in people with HIV/AIDS.
  • Cesamet and Canemes, which contain nabilone (a synthetic substance similar to THC), are approved to treat nausea and vomiting caused by chemotherapy.

 

Outside of these limited cases, there are no FDA-approved uses of cannabinoids. 

 

This brings us to the issue: Should oncologists trust cannabinoids? Nearly everything surrounding cancer is painful. The treatments are painful. The condition is painful. And it is increasingly difficult to get FDA-approved pain medications prescribed, and to get those prescriptions filled by pharmacists. And many patients don’t want the side effects of opioids on top of the side effects they’re already receiving from their chemotherapy. Cancer patients in pain are going to seek out alternative forms of pain relief, and for many, that means cannabinoids. 

 

Because of the widespread use of cannabis for cancer, oncologists should stay informed of the most recent evidence-based data about cannabinoids and how they can help cancer patients. In a recent review article in Frontiers in Pharmacology, the authors set out to inform oncologists about how cancer patients use cannabinoids and what these compounds can do. Please note that these statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease, and this article is not intended to do anything other than keep people informed of research developments. 

Cannabinoids and Cancer Pain

Pain, both physical and emotional, is a common and distressing issue in cancer patients, often leading to high healthcare costs. Chronic pain is especially prevalent among these patients. Current treatments, including opioids, have limitations due to side effects and dependence issues. Neuropathic pain, a type of chronic pain common in cancer, is often resistant to treatment.

 

Cannabinoids, compounds found in cannabis, have been studied for their potential in managing cancer-related pain. They interact with the endocannabinoid system in the body, affecting pain perception and immune responses. Animal studies suggest that cannabinoids can alleviate cancer-related pain, particularly neuropathic pain. Some clinical studies also show benefits, with cancer patients reporting reduced pain and symptom improvement with medical cannabis.

 

Cannabinoids may have an “opioid-sparing effect,” meaning they could reduce the need for opioids in pain management. Preclinical studies indicate that combining cannabinoids with opioids can enhance pain relief. However, clinical trials have yielded mixed results, with some showing benefits and others not. Currently, no cannabinoid-based medications are approved for cancer pain treatment by the FDA or EMA.

 

In summary, cannabinoids show promise in managing cancer-related pain, especially neuropathic pain, and potentially reducing opioid use. However, more research is needed to establish their effectiveness and safety in larger clinical trials before widespread clinical use can be recommended.

CINV

Chemotherapy-induced nausea and vomiting (CINV) is a significant problem for cancer patients, affecting up to 65% with nausea and 25% with vomiting. It’s a major concern because it can impact patients’ quality of life, hinder treatment, and lead to serious health issues like dehydration.

 

CINV happens due to the way chemotherapy affects various receptors in the body, triggering the vomiting process. Several drugs are used to manage CINV, but there are still unmet needs in treating it effectively, especially when it becomes resistant to treatment. That’s where cannabinoids, which use different signaling pathways than other types of pharmaceuticals, may come into play.

 

Researchers have explored the use of cannabinoids to manage CINV. The idea came from the discovery of cannabinoid receptors in areas of the brain involved in vomiting. Both animal and human studies have shown that cannabinoids, like THC and synthetic versions, can be effective in reducing CINV. In fact, synthetic THC called Dronabinol was approved by the FDA for this purpose.

 

Newer cannabinoid-based drugs that contain compounds like THC and CBD for cancer patients are also being tested and have shown promise in reducing CINV. These drugs can be a valuable addition when other antiemetic treatments fail.

Side Effects

While cannabinoids are often said to be safe, research shows that there are risks for certain groups of people. Senior patients with a history of heart disease can develop life-threatening cardiovascular side effects, such as myocardial infarction (heart attack). Most of the research on side effects and negative effects only focuses on the relationship between health and THC– which is only one of hundreds of cannabinoids. There has been comparatively little research done on the health impacts of CBD or THCV, for example. 

 

Another major study focus has been on addiction. Addiction is one of the main concerns that doctors have about the medical use of cannabis, but not only is cannabis rarely addictive, many of the compounds that are used by cancer patients (like CBD) have no addiction potential. 

Conclusion

Cannabinoids, known for their historical use as remedies, have faced research challenges due to strain variability and legal difficulties. With the increasing legalization of cannabis, especially for cancer patients, interest in these drugs has grown. However, aside from their effectiveness in managing nausea and vomiting, cannabinoids lack approval for cancer-related uses. The absence of standardized guidelines complicates the interpretation of real-world data.

 

Despite this, cannabinoids seem to have a positive impact on cancer-related pain when used alongside other pain medications and initiated early in treatment. They also appear to enhance patient well-being by addressing symptoms like mood, appetite, and anxiety. The debate regarding their anti-tumor properties continues, with some data suggesting potential benefits, especially in conjunction with other cancer therapies. 

 

If oncologists want to best serve their cancer patients, they should consider integrating cannabinoids into clinical care. But prescribing cannabinoids requires careful consideration of the patient’s profile. Young patients, pregnant individuals, those with mental health or substance abuse histories, or elderly individuals with severe cardiovascular conditions should avoid them until more safety data is available. Additionally, selecting the right combination of active compounds, dosage, and administration method is crucial to prevent unwanted effects.

 

To fully understand the potential of cannabinoids, more data on their mechanism of action, dosing, interactions with other drugs, and adverse effects are needed. High-quality clinical trials are essential to boost oncologists’ confidence when recommending these drugs to patients.

 

At Myriam’s Hemp, we want everybody to have access to the information they need to make pain relief choices, especially when managing the devastating effects of cancer. Contact us today if you have any questions about our premium cannabinoid products and which ones we recommend.

CBG for Reducing Tumor Progression

Reading Time 7.1 Minutes

Senior doctor looking at x-rays
Image by Unsplash+ in collaboration with Getty Images

In recent years, the potential therapeutic benefits of cannabinoids have gained significant attention. These compounds, all originating from the hemp plant, have great medical potential and have already helped millions of people with their pain and many other conditions. 

 

While CBD and THC are widely known, another cannabinoid called cannabigerol (CBG) is emerging as a promising compound for reducing tumor progression. CBG offers unique properties that differentiate it from other cannabinoids, making it an exciting area of research in the field of oncology. One of its most notable effects is the role it may serve in reducing tumor progression.

What Is CBG?

Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the cannabis plant. It is often referred to as the “mother cannabinoid” because it serves as a precursor to other cannabinoids like CBD and THC. CBG interacts with the body’s endocannabinoid system (ECS), a complex network of receptors found throughout the body, including the immune system and nervous system.

 

CBG’s potential anti-cancer effects are attributed to its interaction with the ECS. Studies have shown that CBG can inhibit the growth of cancer cells by activating specific receptors (CB1 and CB2) in the ECS. These receptors play a crucial role in regulating various physiological processes, including cell growth and apoptosis (programmed cell death). By influencing these processes, CBG may help slow down tumor progression.

CBG and Tumor Progression

Recent studies demonstrate that CBG is an effective tumor suppressant. In one recent study, the effects of CBG, along with CBD and THC, on glioblastoma cells were compared. CBG and THC similarly reduced cell viability, while combining CBD with CBG was more effective than with THC. Both CBG and CBD induced cell apoptosis, and CBG also inhibited glioblastoma invasion, similar to CBD and the chemotherapy drug temozolomide. Adding THC did not provide additional benefits, suggesting that CBG may be a better option for future clinical studies on glioblastoma therapy.

 

Another study found that CBG induced apoptosis and showed positive effects on reducing cell growth in colorectal cancer cells. Interestingly, CBG deactivates the CB2 receptors, which is important for this type of cancer. CB2 receptor activation has been linked to colon cancer progression, which suggests that cannabinoids that interact outside of the main cannabinoid receptors (like CBG) may prove most effective for this type of cancer. 

 

A third research direction is currently looking at CBG in pre-trial studies as a potential treatment for gastrointestinal cancer. While these tests are still in the pre-trial stage, they have found that CBG induces significantly higher rates of cancer cell death compared to other cannabinoids.

 

Older research also highlights CBG’s potential as a treatment for oral cancer. This is another case where CBG doesn’t interact with the two best-known ECS receptors, CB1 or CB2. Instead, a different receptor type entirely– the TRPM8 receptors– play the primary role in this anti-cancer mechanism. 

Combining CBG with Other Treatments

CBG holds immense potential as an adjuvant therapy alongside conventional cancer treatments like chemotherapy and radiation. Studies have indicated that CBG may enhance the efficacy of these treatments while reducing their side effects, such as pain. CBG’s anti-inflammatory properties may help reduce the inflammation caused by chemotherapy, leading to better treatment outcomes.

 

Additionally, lab tests and studies have shown that CBG can be an effective treatment for some side effects of chemotherapy. One study found that CBG robustly improved weight loss induced by Cisplatin, a chemotherapy medication used to treat a number of cancer types. This type of medication is powerful and can create problems with gut function and liver toxicity– which the study found were all partially normalized by CBG. 

 

Additionally, CBG has shown synergistic effects when combined with other cannabinoids, such as THC and CBD. This phenomenon, known as the entourage effect, suggests that cannabinoids work together to enhance their therapeutic potential. Further research is needed to explore the optimal combinations and dosages for the best results.

Taking CBG for Cancer

The potential of CBG in reducing tumor progression is an exciting area of research that offers hope in the fight against cancer. With its unique properties and mechanisms of action, CBG shows promise as an anti-cancer agent by inhibiting abnormal cell growth and reducing inflammation. 

 

The easiest way to take CBG for tumors or other cancer-related issues is to use a high-quality, lab-tested CBG oil. Our CBG oil is a full-spectrum oil, meaning you can benefit from the entourage effect, and is third-party lab tested for your peace of mind. 

 

For those interested in using CBG for cancer, we always recommend when and wherever possible that licensed cannabis medical professionals be consulted. Contact us for a referral by email at customercare@myriamshemp.com, or by phone at (800) 683-4807 ext 1.

 

At Myriam’s Hope Hemp, we believe that everybody should have access to the information they need to make choices about their health. Contact us today if you have any questions about our premium CBD and CBG, as well as our other cannabinoid products like CBGA! 

 

Works Cited

CBD for Mast Cell Activation Syndrome

Reading Time 10.4 Minutes

Mast Cell Activation Syndrome, or MCAS, is a condition that may affect as much as 17% of the US population. However, it is a poorly-understood condition, and many patients with MCAS become frustrated with the treatment they receive from the medical and pharmaceutical industries. 

 

To that end, many MCAS patients look for remedies and relief outside of the traditional pharmaceutical industry. Today, we’re going to explore what MCAS is and talk about some of the treatment options originating with medical hemp.

What is MCAS?

MCAS stands for Mast Cell Activation Syndrome, which is a medical condition characterized by the abnormal activation of mast cells in the body. Mast cells are a type of white blood cell that play a crucial role in the immune system’s response to pathogens and allergens.

 

Mast cells contain granules filled with various substances, including histamine, cytokines, and other inflammatory mediators. When mast cells are activated, these granules are released into the surrounding tissue in a process called degranulation. 

 

Degranulation leads to an inflammatory response that is often painful and debilitating. This activation can occur in response to a wide range of triggers, such as allergens, strong scents, chemical exposures, infections, stress, temperature changes, and certain medications. 

 

In the case of MCAS, mast cells are extremely sensitive and easily triggered, leading to excessive release of inflammatory mediators even in the absence of a major immune system threat. This chronic activation of mast cells can result in a wide array of symptoms that can affect the whole body as a system.

MCAS Symptoms

MCAS has a number of symptoms. Because this is a systemic concern, many of these symptoms affect the whole body. They include, but are not limited to:

  • Skin-related symptoms: Itching, flushing, hives, rashes, and swelling (angioedema).
  • Respiratory symptoms: Wheezing, shortness of breath, nasal congestion, and throat tightness.
  • Gastrointestinal symptoms: Abdominal pain, diarrhea, nausea, vomiting, and bloating.
  • Cardiovascular symptoms: Rapid heart rate, low blood pressure, and lightheadedness.
  • Neurological symptoms: Brain fog, headaches, dizziness, anxiety, and fatigue.
  • Musculoskeletal symptoms: Joint and muscle pain, weakness, and stiffness.
  • Systemic symptoms: Fatigue, malaise, and flu-like symptoms.

 

MCAS treatment is both preventative and reactionary. When we look at medical hemp and how it can be used for MCAS, it is typically used when an activation occurs. 

MCAS and Inflammation

One of the most common reasons that people use medical cannabis or other hemp products is to reduce inflammation. Inflammation is a natural defense mechanism of the body that occurs in response to injury or infection.  

 

However, in the case of MCAS, the excessive activation of mast cells leads to persistent inflammation, even when there is no apparent injury or infection. This chronic inflammation can contribute to a variety of symptoms and health issues associated with MCAS, such as skin rashes, gastrointestinal problems, respiratory symptoms, cardiovascular issues, and even neurological symptoms.

CBD for MCAS

There are several avenues of treatment for MCAS. Some treatment is immediate and deals with the short-term effects of MCAS. When we look at the types of relief that cannabinoids can offer to MCAS patients, one of the first key elements that jumps out is CBD’s anti-inflammatory function.

 

CBD is well-known for its anti-inflammatory properties, so for some symptoms of MCAS, such as rashes and swelling, a topical CBD application can help. Studies show that substances that activate cannabinoid receptors can help reduce the effects of histamine in the human skin. 

 

Creams or lotions that contain substances similar to the ones produced naturally in our bodies, called endocannabinoids, might help relieve itching by reducing the release of granules from mast cells, and decreasing the amount of inflammation-causing histamine and cytokines. Cannabinoids like CBD can also have an analgesic effect on their own, which can help relieve itching and pain from mast cell activation.

CBD and Mast Cell Receptors

We have different receptors in our cells that can interact with cannabinoids. Two of them, CB2 and CB1, are directly related to mast cell inflammation. Of the two, CB2 is better-understood. 

CB2 activation can regulate the production and release of cytokines, which are signaling molecules that control inflammation. 

 

Cannabinoids that interact with CB2 can help decrease the production of pro-inflammatory cytokines and promote the release of anti-inflammatory cytokines, shifting the immune response towards a more balanced and less inflammatory state.

 

Recently, researchers discovered that the CB1 receptor is found in mast cells. Both CB1 and CB2 have effects on mast cells, particularly a molecule called cAMP. cAMP is a messenger molecule found in mast cells, and it is linked to degranulation. A study looking at the relationship between these two receptors and cAMP found that CB1 can cause a long-term increase in cAMP levels in mast cells. An increase in cAMP levels helps prevent mast cells from releasing substances that cause inflammation, which may explain CB1’s anti-inflammatory effects. 

 

CBD interacts with both types of receptors and can stop other substances from activating these receptors. This could explain why CBD can help reduce the unwanted movement of immune cells during a mast cell activation. This study points out that cannabinoids act as potential anti-inflammatory against as part of their general immunosuppressive function, and that the study’s results indicate that exposure to cannabinoids would markedly suppress the acute, inflammatory functions of mast cells. 

CBG and MCAS

CBG (cannabigerol) is another cannabinoid that has potential as a treatment for MCAS. While CBG does interact with CB1 and CB2, it has less has less receptor activity there than CBD does. However, it has much stronger interaction with several other cell signaling pathways, including the transient receptor proteins TRPA1, TRPV1, TRPV2. TRPV3, TRPV4, and TRPM8. Of these, all but TRPM8 have been identified as playing a role in mast cell activation. 

 

  • TRPA1: Activation can lead to mast cell degranulation
  • TRPV1: Associated with pain sensation and contributes to inflammation and degranulation in mast cells. 
  • TRPV2: Not as well-understood but seems to be linked to degranulation and activation in mast cells
  • TRPV3: Linked to the release of histamine in mast cell activation
  • TRPV4: Releases several inflammatory compounds in mast cells.

 

CBG engages with all of these receptors, which may indicate that it can help regulate these cells and prevent degranulation during mast cell activation. 

Other Cannabinoids for MCAS

While CBD and CBG have the most evidence for their effects on mast cells, there is also a case to be made for the entourage effect. In vivo studies have shown that combinations of cannabinoids exert the best anti-inflammatory effects 

 

If you are interested in trying medical hemp for MCAS or other mast cell issues, Myriam’s Hemp offers several full-spectrum, lab-tested products that may help with this inflammatory disease. 

  • CBG 1200, a full-spectrum CBG-forward tincture
  • Daily 100 CBD, a full-spectrum CBD oil that contains other cannabinoids for the entourage effect
  • CBD+CBDa, a unique oil that combines CBD with the more bioavailable CBDa for faster action; very helpful for inflammation
  • CBD Balm, which may help with the itching, swelling, and other skin irritation caused by MCAS

 

At Myriam’s Hemp, we want to provide you with options for managing your health conditions. We believe that everybody should have access to the information they need to make choices about their health. Contact us today if you have any questions about CBD, CBG, and our other premium cannabinoid products. 

 

References

CBD and Skin Health: The Latest Research

Reading Time 10.5 Minutes

There are several ways to incorporate CBD into your wellness routine. Many people like to use it as a tincture, but topical applications are just as popular. CBD-infused lotions and balms have been on the market for years– and now more than ever, we’re learning about what exactly topical CBD can do for the skin. 

 

Today, we’re going to take a look at some of the most cutting-edge research on CBD for skincare and see exactly how CBD interacts with our cutaneous cannabinoid system. 

The Cutaneous Cannabinoid System

The endocannabinoid system is one of the most important parts of the human body. This system of receptors is found in virtually every body system and location. The cannabinoid receptors found in the skin make up the cutaneous cannabinoid system. There are numerous types of cannabinoid receptors found in skin, and studying this system has found that it is directly linked to skin disorders such as dermatitis, psoriasis, scleroderma, eczema, and more. A comprehensive recent literature review identifies even more potential skin issues that can be addressed by CBD. Let’s take a look at some of the major conditions that recent studies have looked at.

CBD for Acne

Forget about the old myth that acne is caused by a dirty face or by eating chocolate. Acne occurs when hair follicles become clogged due to increased oil (sebum) production. Oil production may increase with hormonal changes, bacterial infections, or as a result of skin that is too dry. CBD can decrease the amount of sebum produced by your skin’s glands, which can help prevent acne in the first place.

 

 A 2016 review of cannabis’s medical properties found that cannabinoids had both antifungal and antibacterial properties, which could reduce the appearance of acne due to infection. A 2022 study has shown that both CBD and hemp seed extracts are effective at reducing acne-related skin discomfort and discoloration when applied topically.

CBD for Psoriasis

Psoriasis is a chronic autoimmune skin condition characterized by red, scaly patches on the skin. It is caused by an accelerated skin cell turnover process, leading to the buildup of skin cells on the surface. There has been evidence since 2007 that CBD can help reduce inflammation and cell turnover, both of which play a major role in the painful symptoms of psoriasis. 

 

In more recent research, CBD was found to influence immune system responses by inhibiting the production of pro-inflammatory molecules. CBD can also inhibit the proliferation of certain skin cells and promote cell differentiation, which can help restore a more balanced and normal skin cell cycle.

CBD for Eczema

Eczema, also known as atopic dermatitis, is a chronic skin condition characterized by red, itchy, and inflamed patches on the skin. It is triggered by a number of factors, both environmental and genetic, and can vary in severity. Because eczema is linked to inflammation, the anti-inflammatory properties of CBD make it a likely agent to address this condition. 

 

In 2017, it was discovered that the cutaneous cannabinoid system plays an important role in the appearance and severity of eczema, and that this system can have a major impact on regulating the condition. Another recent study found that CBD is antimicrobial, with some data showing it works well to kill Staphylococcus aureus. Staph infections are a major concern for people with eczema, as it can trigger flares and other complications. 

CBD for Wound Healing

CBD has several properties that can help with wound healing. In addition to the anti-inflammatory and antibacterial properties discussed above, a study in 2022 found that direct application of CBD to a wound encouraged healing. Another study in 2020 found that the interaction of CBD with cannabinoid receptors at wound edges improved long-term healing outcomes. This is due to the way CBD limits the production of over-active keratinocytes– the cells that produce new skin cells. CBD also is an agonist for the CB2R receptor in wound beds, which means that its presence can help regulate the inflammatory microenvironment by reducing the amount of pro-inflammatory triggers. 

CBD for Skin Fibrosis and Scarring

Both skin fibrosis and scarring involve texture changes to your skin.Skin fibrosis is a condition where there is an excessive accumulation of fibrous tissue in the skin, leading to areas of less flexibility and reduced elasticity. Scarring can cause similar changes, but is the result of a wound, lesion, or other disease symptom. 

 

A recent literature review cross-referenced CBD studies on wound healing to determine whether or not it could play an active role in the reduction of skin fibrosis. CBD was found to decrease scarring from both eczema and psoriasis. In another study, it was found to decrease acne scarring, too. 

 

CBD for Sun Damage

Exposure to the sun’s UV radiation can cause oxidative stress on our skin, making it age faster. This leads to cosmetic changes like wrinkles and fine lines, but it also leads to long-term damage to the skin itself. A 2021 study found that CBD reduced many of the effects of  UV damage. It reduced inflammation, controlled protein biosynthesis, and safeguarded proteins from damage caused by UV radiation. These findings suggest that CBD, through its antioxidant and anti-inflammatory effects, could be beneficial in shielding skin cells from the harmful effects of UV radiation. The study also found that CBD helped preserve the healthy lipids found in skin tissue.

 

Another 2021 study, this time a rodent trial, found that CBD was effective as a preventative measure against cellular damage due to UV exposure.  This study looked at how CBD affected the metabolism of skin cells exposed to UVA/UVB radiation. The results showed that both the radiation and CBD treatment altered the expression of proteins related to inflammation and cell death. The CBD treatment helped to mitigate these changes and maintain the normal functioning of the skin cells, suggesting that it could be a protective measure against the negative effects of UV radiation on the skin.

How To Use CBD for Skin Care

If you want to use CBD for any kind of skin condition, the best product is a topical application. A great option for beginners is our 750 MG CBD Balm, which contains a moderate concentration of CBD. This balm can be applied directly to the affected areas of the skin. 

 

For those seeking a stronger application, we also offer a 1200 MG CBD Balm, which has a higher concentration of CBD. Both balms have been found to be effective in reducing skin inflammation and relieving pain in the skin. However, if you’re new to CBD, starting with the lower dose may be sufficient and allow you to gauge its effectiveness for your specific needs.

 

At Myriam’s Hemp, , we want to provide you with the information you need to make choices about your own health. We know that you have many options for relief, and we believe that you deserve to explore them fully. Contact us today if you have any questions about our premium hemp products.

 

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