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CBGa: A Promising Path to Cancer Cell Self-Destruction

Reading Time 11.5 Minutes

One of the big frustrations with cannabis research is how little of it has been done. Due to restrictive US laws, medical research into this powerful plant has been highly limited– and that’s a real shame, because cannabinoids react with the body in ways that many other chemical compounds do not. These unique methods of interaction could have major impacts on cancer cells and other disease tissues.

However, thanks to the 2018 Farm Bill, research on cannabinoids and other hemp products has become easier, and we’ve seen a proliferation of interesting medical studies looking at these chemical compounds. Today, we’re going to discuss a study that looks at the interactions between CBGA and the TRPM7 ion channel, a transmitter in the body that controls many elements of cell survival.

What Is TRPM7, and Why Should I Know About It?

The study we’re looking at today explores the relationship between CBGA and the TRPM7 ion channel’s kinase domain. But unless you’re a chemist or a biologist, that might be confusing. So let’s take a closer look at what these things are and why it’s important to understand them. 

First, let’s look at what an ion channel is and what a kinase domain does. If we want to understand how CBGA impacts TRPM7, we first need to understand what TRPM7 actually is!

What Is An Ion Channel?

Imagine your cells as small rooms in a house, and ions are like guests trying to move in and out of these rooms. However, cells have walls that block most ions from freely entering or leaving. Ion channels are like doors or windows in these walls that can open and close to control the flow of ions. They play a crucial role in regulating the balance of ions inside and outside cells, which is necessary for cell health and proper function.

What Is A Kinase Domain?

Now, let’s look at the “kinase domain” part. A kinase is like a switch that can turn other proteins on or off by adding a chemical tag called a phosphate group to them. Think of it as a way to activate or deactivate certain processes within the cell. The “domain” part just means it’s a specific region of a larger protein molecule that has this kinase activity.

So, when we say TRPM7 has a “kinase domain,” it means it has a part that can act like a switch, influencing other proteins in the cell. This adds another layer of complexity to its function, as it not only controls the flow of ions but also can signal other processes within the cell.

What Is TRPM7?

TRPM7 stands for Transient Receptor Potential Melastatin 7. It’s a type of protein found in the cell membranes of various organisms, including humans. TRPM7 acts as both an ion channel and a kinase. As an ion channel, TRPM7 allows the passage of certain ions, specifically magnesium and calcium, across the cell membrane. This is important for regulating various cellular functions such as muscle contraction, nerve signaling, and cell growth.

Because TRPM7 also has a kinase domain, it can also modify other proteins within the cell by adding phosphate groups to them. This kinase activity allows TRPM7 to influence various cellular processes, including gene expression, cell proliferation, and cell survival.

Overall, TRPM7 plays a crucial role in maintaining cellular function and signaling in the body. Dysfunction of TRPM7 has been implicated in various diseases and disorders, such as cardiovascular disorders, cancer, neurological disorders, renal disorders, and more. This makes it  an important target for research in fields such as physiology, pharmacology, and medicine.

What Is CBGA?

Cannabigerolic acid (CBGA) is a cannabinoid that’s best described as a precursor molecule in the biosynthesis of various cannabinoids found in the cannabis plant. CBGA is the “mother molecule” that turns into THC, CBD (cannabidiol), CBC, and all other cannabinoids. CBGA itself does not possess psychoactive effects like THC, but it plays a crucial role in determining the types and quantities of cannabinoids produced by the plant. CBGA influences the overall chemical profile and therapeutic properties of the hemp plant. Research into CBGA has found that it can have numerous positive effects on seizure conditions, neurodegenerative conditions, colon cancer, and more. 

What Does CBGA Do To TRPM7?

Before we go any further, we do want to point out that these statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is simply sharing information about a new medical study.

TRPM7, like other TRP ion channels, is linked to cancer cells developing. While the direct relationship between TRP ion channels and cancer is complex and not fully understood, emerging evidence suggests that these channels can influence cancer progression through several mechanisms. One of these is calcium signaling. Many TRP channels are permeable to calcium ions, and alterations in calcium signaling have been implicated in cancer development and progression. Dysregulation of calcium levels can affect key cellular processes such as cell proliferation, migration, invasion, and apoptosis (programmed cell death), which are all critical aspects of cancer biology. Inducing apoptosis in cancer cells is one of the primary mechanisms that allows cancer to be fought, since apoptosis kills the diseased cells without targeting or impacting healthy cells.

These ion channels also regulate the production of new blood vessels. This process, called angiogenesis, is essential for tumor growth and metastasis, as it provides nutrients and oxygen to cancer cells and facilitates their spread to distant organs. TRP channels may influence angiogenesis through their effects on endothelial cell function, and the release of pro-angiogenic factors. 

There is also emerging evidence that suggests that certain TRP channels may confer resistance to chemotherapy drugs by modulating the way cells receive signals. TRP channels and calcium signaling can impact drug efflux mechanisms in cancer cells, which means that when TRP channels are active, they make it harder for cancer medication to work. Targeting TRP channels could potentially overcome chemoresistance and improve the efficacy of cancer treatment.

Some TRP channels, such as TRPC1 and TRPM7, have been shown to promote cancer cell migration and invasion by regulating cytoskeletal dynamics and cell adhesion. These processes are crucial because they allow cancer cells to invade surrounding tissues and metastasize to distant sites in the body. In particular, overexpression of the TRPM7 calcium ion channel is linked to poor prognosis in breast cancer. So finding a way to regulate the TRP ion channels is an important tool in the fight against cancer.

That’s where CBGA comes in. This study was conducted after in vivo rodent tests revealed that  CBGA could protect kidneys from damage and reduce inflammation by blocking these TRP ion channels. This study investigates how different cannabinoids affect these channels, and it turns out that half of the tested cannabinoids can partially block them. CBGA stands out as the most effective at blocking the TRP channels, especially TRPM7. The study found that CBGA’s ability to block TRPM7 relies on its kinase domain. The findings suggest that CBGA could be a powerful tool in treating diseases where TRPM7 is involved, like cancer, stroke, and kidney disease.

But CBGA doesn’t just inhibit TRPM7. It also regulates SOCE. SOCE stands for “Store-Operated Calcium Entry.” It’s a fundamental process in cells that involves the regulation of calcium ions (Ca2+) entering the cell from the extracellular space. The increase in intracellular calcium concentration resulting from SOCE activation triggers various cellular responses and signaling pathways. These responses can regulate processes such as cell proliferation, gene expression, neurotransmitter release, muscle contraction, and immune cell activation. SOCE plays a critical role in maintaining calcium homeostasis within cells and is involved in a wide range of physiological processes. Dysregulation of SOCE has been implicated in various diseases, including immune disorders, neurodegenerative diseases, cardiovascular diseases, and cancer. 

So what does CBGA do? Essentially, it strongly limits cancer cells’ ability to transmit information via a specific type of calcium channel: CRAC channels. CRAC channels, short for “Calcium Release-Activated Calcium” channels, are specialized ion channels found in the membranes of many types of cells, including immune cells like T lymphocytes. These channels play a crucial role in regulating the influx of calcium ions into cells in response to specific signals. When these signals are inhibited, the cells are unable to grow and often die off through apoptosis. This means that this type of calcium signaling inhibition can have amazing therapeutic potential for various medical conditions. Some of the medical conditions in which CRAC channel inhibitors might be useful include autoimmune and allergic disorders, transplant rejection, pancreatic diseases, chronic pain, and various cancers. By being able to regulate and control both TRPM7 and CRAC channels, CBGA looks like it may be an important tool in the fight against cancer. 

If that wasn’t enough, the researchers also found that CBGA also highly inhibits the production of cytokines, inflammatory chemicals that are often responsible for kidney damage and other organ injury. This is also related to TRPM7 function, as TRPM7 has been implicated in the regulation of cytokine production and inflammation. This shows that CBGA’s effects on TRPM7 extend beyond its role in ion channel activity, highlighting its potential as a therapeutic agent for conditions associated with inflammation and cytokine-mediated tissue damage.

Ultimately, this research is an important step in understanding the role that CBGA may play in medical care. While more research is necessary, this study represents an important step forward in anti-cancer research.

At Myriam’s Hemp, we want everybody to have access to the information that they need to make decisions about their wellness. We got our start when our mom was fighting her own battle with cancer, and we know how hard these decisions can be. Don’t hesitate to reach out to us with any questions you have about our premium hemp products!

FDA Disclaimer: The claims in this blog post are not intended to diagnose, treat, cure, or prevent any disease, and these statements have not been evaluated by the Food and Drug Administration. Please consult your healthcare professional about potential interactions or other possible complications before using any CBD product.

What Is CBDV?

Reading Time 8 Minutes

What Is CBDV?

The hemp plant contains numerous cannabinoids– life-enhancing chemicals that interact with our bodies endocannabinoid system. Estimates range from 60 to over 140 of these different compounds, and as hemp research continues to develop, we are learning more and more about different cannabinoids every day.

One of these cannabinoids is cannabidivarin or CBDV for short. CBDV was first isolated in Germany in 1969, but research since then has been limited. This is true for many cannabinoids other than CBD. However, the research shows great promise for CBDV as a helpful compound that compliments other cannabinoids. 

CBDV Research

Chemically, we know that CBDV is structurally similar to CBD. It is a homologous molecule to CBD, which means that the basic structure is the same and the two molecules are differentiated by repeating elements such as side chains of different lengths or a peptide residue. In layman’s terms, this means that homologous molecules may have similar properties, and this does seem to be the case with CBD and CBDV. 

Biologically speaking, there are some major differences. CBD is relatively abundant, and commercial hemp strains may contain up to 30% CBD content. CBDV, however, isn’t even found in all strains of hemp. It isn’t even found in all hemp plants, and usually only makes up less than 1% of any hemp plant’s cannabinoid content. 

There are some African landrace strains of hemp that have up to 4% CBDV content, and some hemp breeders have experimented with plants and gotten results of up to 7% CBDV content. But 7% is still a long way from the quantities of CBD hemp plants can naturally produce. Also unlike CBD, CBDV is not easily produced in a lab from precursor compounds. 

Adding to the challenge of acquiring large quantities of CBDV is the fact that it is largely limited to landrace plants. Landrace hemp strains are naturally-growing hemp varieties that have not been crossbred with other strains. These plants must exist in relative isolation and have not been selected for favorable traits like commercially grown strains. CBDV is primarily found in Cannabis indica landrace plants originating in Africa, but it can also be found in somewhat elevated concentrations in indica landrace strains from Pakistan, India, and Mexico. 

While these plants can be farmed, they must be kept away from other plants to avoid the risk of cross-pollination. CBDV production is not a dominant characteristic in hemp plants, and it is a minor cannabinoid with an unknown botanical function. All of this means that there have been major stumbling blocks in researching CBDV. Even though it was first isolated in 1969, the first major research was not undertaken until 2012. There’s a lot that we don’t know yet about CBDV, but the research is very exciting.

Despite the difficulty in getting large quantities of CBDV, research has shown that it has promising effects on health. This is partially in part to how it interacts with the body. Unlike most cannabinoids, it does not react with the endocannabinoid system. Instead, it activates or desensitizes the transient receptor potential channels (TRP channels). The TRP channels play critical roles in managing our sensory systems and allow cells to detect changes in their environment. This system is linked to a number of sensory issues, as well as epilepsy and other types of seizures.

CBDV for Seizures

Beyond its anticonvulsant properties, studies have shown that there is a molecular component to the effectiveness of CBDV for epilepsy. One major study has shown that CBDV is effective in treating seizures from a variety of causes in rodent models. Additionally, CBDV treatment did not impact motor skills after recovery. This is a concern with some anti-seizure medications, and an anticonvulsant that does not cause impairments in motor skills shows potential for long-term use by chronic epilepsy patients. 

In further rodent trials, CBDV has even been shown to have an effect on epilepsy-related gene expression in brain tissues after seizures. The brain tissues’ responses were rapid and acute, and the CBDV seemed to interact directly with the brain instead of just the endocannabinoid system’s receptors. As in other trials, motor skills were also unaffected during post-seizure recovery. This indicates great promise for CBDV as a seizure medication. 

Drug trials for a CBDV-based seizure medication are already in progress. The pharmaceutical company GW Pharmaceuticals, manufacturers of the CBD-based Epidiolex, is currently recruiting for Stage III trials of their CBDV-based anti-convulsant for temporal lobe seizures. 

CBDV and Rett Syndrome

Rett Syndrome is caused by mutations on the X chromosome, it is characterized by the impairment of cognitive, sensory, emotional, motor, and autonomic function. Symptoms include repetitive hand movements, slower brain growth and intellectual disability. A rodent trial found that CBDV may contribute to reversing the deterioration and atrophy of the brain areas involved in Rett syndrome, and human trials demonstrated that a dose of 10 mg per day of CBDV a day significantly reduced seizures. 

Additionally, this trial showed that  Rett Syndrome patients who took CBDV also scored higher in areas including sociability, general health, brain weight, and hormone activity in the hippocampus (the part of the brain responsible for emotion and memory). This suggests that CBDV may also help with the non-seizure aspects of Rett Syndrome.

CBDV and Autism

CBDV has also been investigated for its therapeutic use for people on the autism spectrum. CBDV reacts with the brain’s excitation pathways, which are easily overstimulated and lead to repetitive behaviors that can interfere with an autistic person’s quality of life. CBDV is currently being trialed as a way to help autistic people manage their behavioral symptoms and mental health concerns. Additionally, autism and epilepsy frequently occur together, so a compound that can treat issues stemming from both may be beneficial to many people. 

CBDV also shows promise as a treatment for children with intellectual disabilities and may reduce the number of severe behavioral problems in these children, making it easier to keep them safe and care for them. CBDV is much gentler than sedatives, benzodiazepines, and other depressants. Additionally, it seems to have fewer short term and long term side effects and does not have a long term negative effect on gross motor skills, meaning that is likely a safer alternative to help these children.

Other Benefits of CBDV

Like many other cannabinoids, CBDV is effective at reducing nausea. This has been shown in studies using various animal models and is not surprising given that the first medically approved use for any cannabinoid was for nausea and vomiting. 

CBDV also shows promise as an acne treatment when used topically due to its anti-inflammatory nature. CBDV reduces the buildup of dead skin cells and lipids that form around inflamed skin, which is what causes acne breakouts. This is a topical application of CBDV and other key cannabinoids. 

How To Take CBDV

There is no psychoactive component to CBDV. It will not get you high or cause any kind of motor impairments. However, despite being totally legal in the United States, it can be difficult to find CBDV for sale. This is because landrace hemp strains are not the same things as commercial hemp, and so there are more restrictions around this kind of hemp. Furthermore, landraces typically contain a higher THC content than is allowed to be commercially grown in the United States. This means that acquiring pure therapeutic CBDV can be a challenge. 

We hold the CBDV that we offer here at Myriam’s Hemp to the same high standards of purity and quality that we hold all of our CBD products. You can rest assured that the CBDV we offer is made with natural, organic, high-quality ingredients. This includes our carrier oils, as well as the cannabinoids we offer. All of our products are lab tested and guaranteed to be free of sugars and other fillers.

Our CBDV tincture is best taken like all of our other tinctures. Simply use the dropper to place your dosage under your tongue, or mix it into a beverage if you prefer to take it that way. 

Buy CBDV at Myriam’s Hemp

At Myriam’s Hemp, our goal is to help you make the most of your cannabinoid experience. We believe in our products and want to help you take control of your health by offering premium hemp products, like CBD, CBG, CBN, CBDA, CBGA, and CBDV tinctures and topicals.

Our cannabinoid products are created with quality at the forefront, and we are constantly striving to enhance our offerings. Our products are designed with the goal of providing you with the relief you’re looking for and helping you manage your health without total reliance on traditional pharmaceuticals. Shop Myriam’s Hemp online and order your cannabinoid products today.


How To Get Rid of Brain Fog

Reading Time 4 Minutes

Brain fog is a chronic mental syndrome that combines cognitive fatigue, judgment issues, and memory impairment for an overall feeling of discomfort and disorientation. It has garnered attention recently as a symptom of COVID-19. This catch-all term has a number of contributing factors and can be tricky to understand. 

What Is Brain Fog?

Brain fog is the term used to describe a number of symptoms that all contribute to an overall uncomfortable feeling of being “spaced out” or mentally sluggish. Brain fog feels like a lack of mental clarity. When you’re dealing with it, it can be hard to focus or pay attention, and it makes it difficult for you to recall things.

Brain fog doesn’t necessarily hurt and it usually isn’t accompanied by pain. That said, brain fog can lead to additional symptoms, including prolonged or worsened sleep disorders, gastrointestinal dysfunction, and a decreased metabolism.

It can also have wide-ranging effects on your mental and emotional health. Brain fog can be confusing, frustrating, and upsetting. It can make problems seem much worse and make you feel like you’re losing control over small details, which is often quite distressing.

What Causes Brain Fog

There are lots of contributing factors to brain fog. It can be the result of numerous health conditions, including hormonal conditions and chronic health conditions. The following conditions are all associated with brain fog:

  • Insomnia
  • Stress
  • Dementia
  • Depression and other mental illnesses
  • Medication side effects
  • Thyroid disorders
  • Multiple sclerosis
  • Migraines
  • Cancer
  • Chronic inflammation
  • Head injuries
  • Nutrient deficiencies 
  • Chronic fatigue syndrome
  • Menopause
  • Viral infections, including COVID-19 

How Can CBD and CBDA Help With Brain Fog?

Because brain fog has so many different causes, we don’t know how many people suffer from it. However, neuroscientists point out that about 600 million people suffer from cognitive dysfunction. 

Cognitive dysfunction is a symptom that many people choose to address with CBD or CBDA. Studies have shown that CBD has therapeutic effects on many different areas of the brain, improving limbic system activity, cognitive pattern recognition, and overall performance of cognitive tasks and functions.

This is likely because of how CBD interacts with receptors in the body’s endocannabinoid system. The endocannabinoid system is a biological system that impacts your mood, pain sensation, mental function, and various other important bodily functions. CBDA also has impacts on your mood and mental function, but it works somewhat differently than CBD. 

CBDA interacts with our serotonin system, and through its interactions with this neurotransmitter, CBDA can have a powerful effect on the mind. CBDA is the precursor to CBD and is less well-known than CBD. Both CBD and CBDA can help fight brain fog, but they do so using different chemical receptors and signal mechanisms.

While less is known about everything that CBDA can do, CBD works to fight brain fog in a number of ways. Here are some of the ways that cannabinoids like CBD can directly impact brain fog.

Cannabinoids Reduce Inflammation

Research has shown that CBD can reduce inflammation throughout the body. Inflammation is linked directly to brain fog, especially in patients with post-COVID-19 neurological symptoms

Cannabinoids Promote Good Sleep

Sleep deprivation is a common root issue of brain fog, and CBD in particular has performed well in recent studies relating to sleep regulation.

Cannabinoids Reduce Anxiety

The use of CBD influences the activity in certain parts of your brain that are connected to stress, depression, and anxiety. The same is true of CBDA as it interacts with your serotonin system. A reduction in anxiety can improve your overall brain function, and research shows that CBD and CBDA are helpful for people with anxiety.

Boost Your CBD Tincture

More than half of all CBD users take the cannabinoid to address mental health concerns. A full-spectrum CBD tincture like our Daily 50 CBD Oil or our Premium CBDA Oil will engage the cannabinoid receptors in your brain and may lead to improved cognitive function, including improved memory, clarity, and focus.

If you want to take CBD or CBDA specifically to address the “fuzzy” feelings of brain fog, you can choose to add the Focus Terpene Boost blend to any of our tinctures. This is a proprietary blend of specific terpenes that are geared to enhance your experience by improving focus, clarity, and cognitive function. Simply scroll down before you add your tincture to your shopping cart and choose the Focus Terpene Boost– it’s that easy.

Buy CBD and CBDA at Myriam’s Hemp

At Myriam’s Hemp, we want to help you improve your life and make the most of your cannabinoid experience. Our goal is to provide hope to those who are suffering from conditions that can have a significantly negative impact on everyday life. Our cannabinoid tinctures and topicals are created with quality ingredients that may provide you with the relief you’re looking for. Shop Myriam’s Hemp online and order your cannabinoid products today.

CBG for Anxiety & Mental Health

Reading Time 5 Minutes

Cannabis and hemp possess a virtually infinite potential for the world of health and wellness and have already proven to be both physically and psychologically beneficial by amateur and anecdotal experience and scientific investigation. Cannabigerolic acid—also known as CBGA—is one of the many derivative byproducts of hemp, and emerging studies are beginning to highlight its amazing benefits in the realm of mental health.

What are CBGA and CBG?

Before we dig into how CBGA and CBG can help your brain, let’s take a quick look at what they are and how they work.

Both CBG and CBGA are cannabinoids, and they share this classification with better-known cannabis derivatives, like THC and CBD. In its acidic form, CBGA (sometimes written as CBG-A) breaks down into one of the many cannabinoids. In some instances, it may break down into CBG.

Right now, CBG research is in its infancy. Compared to many of the other cannabinoids, it hasn’t seen as much scientific or social interest. However, with technology and efforts surrounding cannabis legalization growing daily, more studies are being conducted on CBGA and CBG than ever before.

CBG works by binding to both CB1 and CB2 cannabinoid receptors in the brain, nervous system, and immune system, providing full-body benefits and protection. Once in your body, CBG helps to increase the production of anandamide. Anandamide is a neurotransmitter that helps with pain regulation, sleep cycles, appetite, and motivation/mood.

Because this cannabinoid is lesser-known and less studied, CBG is more difficult to find in the marketplace. While you may find CBG for sale at a local dispensary, it’s not a common item to find.

Fortunately, Myriam’s Premium Hemp Products online store is always open, and we stock plenty of CBG oils and tinctures. Keep reading to explore more about CBG

Does CBG Make You High?

No! CBG does not make you high. 

CBG is a nonintoxicating cannabinoid, unlike the more popular ones like THC or THCA. Taking CBG does not impact motor function or perception, and is safe to take if you prefer to avoid intoxicants.

CBG for Mental Health

Aside from its many physical benefits, CBG has been shown to improve mental health. Its use has been reported to alleviate a variety of psychiatric symptoms, and respondents in one study even lauded CBG as a more effective treatment plan than their conventional medicinal routine.

CBG & Anxiety

Anxiety is a huge problem in the modern world. We are constantly surrounded by stimulation, and our stress will often morph into anxiety. While there are plenty of treatments available, many of them often cause negative side effects, or just don’t give you the relief you want. Fortunately, CBG is different, and can safely be taken alongside other methods of alleviating anxiety.

Does CBG Work for Anxiety?

CBG has been proven to alleviate symptoms of anxiety, and studies suggest that it does so without the negative effects of many standard pharmaceuticals.

While we don’t know exactly why this is, we do know that CBG promotes muscle relaxation. Paired with its ability to promote dopamine production, CBG mimics the way we naturally deal with anxiety.

Think of it as a massage for your mind. When you’re feeling stressed and anxious, you’ll often find a spot to relax and unwind. When you’re lounging on your sofa, you’re relaxing your muscles. At the same time, your brain is releasing plenty of dopamine, which is responsible for happy thoughts and positive feelings.

CBG for Depression

Thanks to the release of dopamine, CBG also doubles as a potent ward against depression.

Many of the physical effects of CBG are also linked to common causes of depression. One of the most common is chronic pain, which is often relieved by CBG’s anti-inflammatory properties.

For individuals with other ailments, such as AIDS or cancer, CBG is also shown to stimulate appetites. As a result, many users report feeling more energized, as they are naturally encouraged to eat a hearty meal after using CBG.

Where Can I Get CBG?

We’ve already mentioned it, but let’s look a little deeper into the issue of availability. Because CBG is not one of the more popular cannabinoids, it tends to be harder to find.

At Myriam’s Premium Help Products, we always stock high-quality CBG products. We’re also proud to feature two amazing CBG products, and you can easily purchase them directly from us.

CBG 600

Myriam’s Hope Hemp always guarantees that your product will be fantastic, and that’s why we have proprietary blends – we want formulas we can trust. One of these is CBG 600. This mix contains 600 mg of CBG per ounce, which means it packs a real punch! All of our CBG products are full-spectrum, which means you aren’t missing out on any of the essential components of this beneficial cannabinoid. If you are interested in adding additional terpenes to boost flavor and wellness benefits, we can customize any CBG order.

CBG 1200

In addition to our classic CBG 600 tincture, Myriam’s Hope Hemp also offers our NEW CBG 1200 blend. This tincture doubles the amount of active CBG to 1,200 mg per ounce, and it still has the flexibility of our classic CBG 600. Remember, adding additional terpenes can give you a custom blend with added benefits just for your particular needs.

The Myriam’s Hope Hemp Difference

At Myriam’s Hope Hemp, all of our proprietary products are made in the USA. Each tincture, oil, and bottle is rigorously tested to ensure maximum efficacy and absorption. Everything is sugar-free and vegan friendly, which means that everyone can get the all-natural relief that they need.

In addition to our fantastic tinctures, Myriam’s Hope Hemp also offers premium CBD-based topical treatments. If you’re looking for a new way to treat the woes of modern life, then check us out! We’re more than happy to help you find the perfect blend.

What Is CBGA

Reading Time 10 Minutes

The cannabis plant is full of life-enhancing compounds called cannabinoids, and no one knows precisely how many there are; the number may be as high as over 140! We are still discovering more about cannabinoids and their uses every day.

One of these cannabinoids is cannabigerol acid, or CBGA. This non-psychoactive cannabinoid compound has many valuable properties and is one of the few cannabinoids that has received substantial scientific investigation. Here, we cover what you need to know about CBGA and share what we know about this unique compound.

CBGA’s Botanical Function

When a hemp plant starts growing, it only produces one cannabinoid: CBGA. All of the others are derived from this cannabinoid. CBGA is a precursor compound produced in the hemp plant’s trichomes. In the plant, it triggers targeted cell necrosis in the leaves, essentially telling them when to die so that the plant can put more energy towards the flower.

As a precursor compound, CBGA is a foundational compound of the cannabis flower’s other major compounds as a precursor compound. This means that it is at the top of the chain reaction that produces the three major cannabinoid lines: THCA (tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), and CBCA (cannabichromenic acid). These, in turn, become THC, CBD, and CBC. CBGA can also convert to CBG, but in most strains of cannabis, CBGA converts into THC or CBD. This has made CBGA extremely important in hemp research!

Most of what we know about CBGA comes from research on the compounds it turns into. In the 1960s, Israeli researchers isolated CBG; in the 1990s, Japanese researchers discovered that it came from CBGA. Since then, most CBGA research has focused on how to convert it to other cannabinoid compounds. Primarily, this involves synthesizing THCA (and often subsequently THC) for research and pharmaceutical purposes.

The ability to synthesize CBGA is important because it is difficult to keep intact. While CBGA is found in large quantities in young plants, exposure to heat immediately starts the chain reaction that converts it to another molecule. Additionally, most of the CBGA a cannabis plant makes over its life becomes THC or another compound through the plant’s own biological processes.

This has led to advanced research in biosynthesis, and as recently as 2019, researchers discovered how to synthesize CBGA and other cannabinoids in yeast. This means that research on this compound and what it can do will be much easier going forward, as the researchers are not limited to harvesting the minute quantities that the hemp plant naturally produces.

How Does CBGA Work?

CBGA, like all cannabinoids, acts by binding to the body’s endocannabinoid system. This system of receptors is dispersed all throughout the body and only activates in the presence of cannabinoids. When CBGA is converted to CBG, it binds to CB1 receptors that act directly on the brain and nervous system without having a psychoactive effect. CBGA on its own, binds to CB2 receptors, which are involved in the immune system and gastrointestinal system.

What Can CBGA Do For You?

Most of the existing research on CBGA focuses on its transformation to THCA, CBDA, or other cannabinoids. This means that most research on the benefits of CBGA is connected to its use after that transformation. But as we learn more about CBGA, researchers are finding that it has many potential benefits of its own.

COVID-19 Prevention

One of the most recent findings is that CBGA, along with CBDA, may successfully prevent COVID-19 transmission and infection. The cannabinoids prevent infection by binding to the SARS-COV-2 spike protein. This prevents it from entering the cell and reduces the chance of infection. It also shows promise in preventing and treating new variants of COVID-19. While these are preliminary findings and substantial additional research and testing are necessary before truly being considered a treatment for COVID-19, this research is very promising.

Cardiovascular Disease

In vitro studies of CBGA have found that the compound significantly inhibits the enzyme aldose reductase. This enzyme is a major contributor to oxidative stress that leads to heart problems, as well as other negative effects on the body. This research is valuable because synthetic inhibitor drugs have severe negative side effects for many patients. A plant-derived inhibitor drug based on CBGA could help millions of people who suffer from cardiovascular disease or cardiovascular symptoms of metabolic diseases like diabetes.

Inflammation Relief

Rodent studies show that CBGA has a powerful positive effect on some of the metabolic receptors that trigger inflammation. Additionally, CBGA can also inhibit the action of cyclooxygenase enzymes, more commonly known as COX inhibitors. COX inhibitors reduce the production of prostaglandins, which are chemicals that the body produces to help reduce inflammation. By inhibiting the inhibitors, CBGA helps reduce inflammation and pain in the body.

Seizure Treatment

CBGA is a potentially powerful anticonvulsant treatment for seizure disorders like epilepsy. Cannabis has been used to treat epilepsy for thousands of years, and today’s modern hemp-derived epilepsy treatments contain little to no THC. Instead, other cannabinoids are the primary focus. The best known and best understood is CBD, but minor cannabinoids like CBGA show a lot of promise in anticonvulsant research. CBGA has been found to react with numerous seizure-related receptors and is highly effective in certain induced seizure conditions in mice. This could translate into support for an increase in CBGA as a treatment for seizures in humans as well.

Metabolic Disease

CBGA may also help patients with metabolic disorders due to its reaction with peroxisome proliferator-activated receptors (PPARs) that regulate metabolism. When PPARs do not function properly, people accumulate lipids excessively and develop metabolic diseases like diabetes and high levels of cholesterol and triglycerides. One study shows that cannabinoid acids like CBGA are PPAR agonists, which means that they can help regulate PPAR expression. Another study found that cannabinoids positively regulate PPAR-associated genes that control lipid metabolism.


In addition to regulating PPAR activity, CBGA also has other regulatory properties. One of these is its ability to protect against the neurodegenerative effects of Huntington’s Disease. In this study, it was found that acidic precursors like CBGA are demonstrably more effective than their
subsequent cannabinoids. This was seen in both cell line studies and rodent studies and is a very promising line of research.

Additionally, CBGA may protect against the neurotoxicity that stems from the stress of oxidation particles, hydrogen peroxide (H2O2), and rotenone, which causes mitochondrial dysfunction. In this in vitro study, a high concentration of CBGA dramatically reduced the rotenone-induced neurotoxicity. CBGA is also shown to prevent the formation of superoxide radicals, which eventually reduces oxidative conditions that lead to neural degeneration. In other words, it’s a powerful antioxidant that can help protect your cognitive function as you age.

Colorectal Cancer Treatment

While it is important to note that the research is in very early stages, CBGA may one day be a vital treatment for patients with colorectal cancer. Colorectal cancer is the third most common cancer and is the fourth leading cause of cancer-related death, so additional therapies and treatments will save many lives. As we mentioned previously, CBGA has cytotoxic or cell-killing effects that tell the plant to redirect energy to the flower instead of the leaves. Its primary job is to tell cells when to die. The effect may not be limited to cells in the hemp plant.

Research shows that these cytotoxic effects also have an effect on colon cancer cells. In experiments on colon cancer cell lines, CBGA killed colon cancer cells, sped up early cancer cell death, and stopped the cancer cell cycle. Additionally, the research is encouraging in regards to preventing the growth and spread of cancerous polyps, which grow into potentially lethal carcinomas.

How To Get CBGA

CBGA is found in all varieties of the hemp plant, including hemp plants that produce low amounts of THC. This means that it’s legal in all 50 states! While CBGA is not mentioned specifically by name in the 2018 Farm Bill or other cannabis laws, it can be derived from hemp plants that contain virtually no THC. Additionally, CBGA is not psychoactive, so it is generally treated with the same considerations as other non-psychoactive cannabinoids. Since CBGA is completely legal, it can be found in a number of locations. Hemp shops and CBD retailers will likely carry CBGA products, as will shops that cater to specialty health concerns and wellness, such as Myriam’s Hemp. Be sure to specify that you are looking for CBGA and not the more commonly-known CBG, as the two have different effects!

How To Take CBGA

If you’re interested in trying CBGA, there are several different ways you can consume it. Remember, CBGA is very susceptible to heat, and as soon as it is exposed to heat, it begins the reaction that changes it into another cannabinoid, typically CBG. That means you probably won’t have much luck consuming it through any leaf-based method, as most of those involve heat.

Even if you keep the temperature low, the drying and curing process itself can also have an effect on the amount of CBGA available to consume. Smoking, vaping, or baking into food will transform your CBGA into CBG, so those routes just are not ideal if you want the full CBGA benefits. And while CBG is helpful in and of itself, it provides different benefits than CBGA!

Tinctures, on the other hand, are a much more reliable way to take CBGA. CBGA can be synthesized in a lab and distilled into a tincture that you can take just like any other cannabinoid tincture. When you choose a CBGA tincture, you should make sure to choose one from a company that is transparent about lab testing and one that uses all-natural ingredients for your safety.

You should also know that cannabinoid precursors, including CBGA, are not present in all types of tinctures. A CBG tincture is not going to contain CBGA. A broad or full spectrum tincture may contain CBGA, along with many other cannabinoids, to enhance the entourage effect.

If you’re looking for specific CBGA responses, however, your best bet is to choose a full spectrum CBGA tincture with a higher concentration of CBGA compared to the other cannabinoids to allow the cannabinoid to shine through. In the coming weeks, we will be releasing our own all-natural CBGA tincture for healthful relief.

Buy CBGA at Myriam’s Hemp

At Myriam’s Hemp, our goal is to share useful information that will help you make the most of your cannabinoid experience. We believe in our products and want to help you take control of your health by offering premium hemp products. We provide hope to those who are suffering from diseases that can have a significantly negative impact on everyday life.

Our cannabinoid products are created with quality at the forefront, and we are constantly striving to enhance our offerings. Our online store features a variety of CBD, CBG, CBN, CBDA, and soon, CBGA products that may provide you with the relief you’re looking for and help you to manage your health without total reliance on traditional pharmaceuticals. Shop Myriam’s Hemp online and order your cannabinoid products today.


Can CBDA Help Prevent COVID-19? A New Study Says YES!

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Science says yes

It’s common knowledge that CBD from hemp can help lower inflammation and strengthen your immune system overall. A new study done by Oregon State University researchers has found that CBDA, a parent molecule to CBD, may actually help in the prevention of the COVID-19 virus and its variants.


How Does Cannabis Help with COVID? What the Study Says

Researchers have already known for a while now what CBDA can do to alleviate inflammation, digestion, and much more (see the last section in this article for more information about that). What an exciting new study at Oregon State University found out recently, however, was what this CBD precursor may be able to do to protect against the virus that produces COVID-19 as well.

A team of scientists at the Linus Pauling Institute at Oregon State University in Corvallis, OR, in partnership with investigators at Oregon Health & Science University in Portland, recently discovered that both CBDA (cannabidiolic acid) and CBGA (cannabigerolic acid) have the ability bind to SARS-COV-2 spike protein. Both of these cannabinoids are found in hemp variations of cannabis.

This is a huge discovery because it means that CBDA and CBGA may have the ability to prevent the spike protein from entering cells and causing COVID-19. The Oregon State University report was published January 10th, 2022 in the Journal of Natural Products. (1)


Can CBDA Also Protect Against New COVID Variants?

According to the University of Oregon researchers, the answer could also be yes.

Dr. Richard Van Breeman, principal investigator at the Linus Pauling Institute and professor of chemistry at Oregon State, commented in a recent interview that CBDA and CBGA may be effective against emerging COVID variants as well. Two variants mentioned in the study include “B.1.17” (Alpha variant) and “B.1.351” (Beta variant).

Both Alpha and Beta are currently classified as “VBM” (Variants Being Monitored) by the U.S. Centers for Disease Control. (2) According to Yale University, the Alpha variant was first discovered in the UK in November 2020. Until the emergence of Delta, it was the predominant variant amongst infected individuals in the US.

Also, according to Yale, the Beta variant was discovered in South Africa at the end of 2020. So far it has not been as widespread. Experts state, however, that it is about 50% more contagious than the original virus and potentially 20% more contagious than the Alpha variant. (3)

“Orally bioavailable and with a long history of safe human use, these cannabinoids [CBDA and CBGA], isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2,” the report authors state.


More on CBDA

A lot goes into the creation of the cannabinoids most people are familiar with that are found in both medical marijuana and hemp. CBDA and CBGA, which are major players in the formation of CBD, CBG, and CBN are considered “parent molecules”. In other words, those cannabinoids are created first and then CBD and other cannabinoids eventually emerge from them.

 CBDA specifically is considered a powerful healing substance in its own right. That being said, CBDA actually works much differently than CBD and THC cannabinoids in the body. The main difference is that CBDA does not interact much with the endocannabinoid system. It does not bind with CB1 nor CB2 receptors. Instead, it interacts with receptor sites for certain brain and nervous-system precursors such as 5-HT. 5-HT is a chemical needed for the production of serotonin. CBDA also interacts and influences key enzymes to produce its healing effects.

CBDA also affects the production of serotonin itself and the way this hormone interacts in the body. Serotonin is mostly known as a neurologically influential hormone that produces feelings of happiness and fulfillment.

Serotonin does a lot more than this in the body overall, however. It is a key hormonal substance for emotional regulation and the proper functioning of motor skills. It also influences digestion, sleep cycles, and cardiovascular health. According to a 2017 study conducted at the University of Freiburg in Germany, serotonin also plays a part in cytokine and T cell production in the immune system, amongst other things. (4)

Besides being a potential preventative against various strains of COVID, research into CBDA has found that it can also be beneficial for depression symptoms, digestive issues such as nausea and vomiting, brain and nervous system conditions, such as seizures, and for lowering inflammation overall. (5) (6)


How Can I Obtain CBDA?

Oregon State University researchers present hopeful research for the possible natural prevention of this dreadful virus that has changed the way the whole world functions. Recent research has found that CBDA in particular is more readily absorbed into the bloodstream and body than regular CBD. What’s more, both CBDA and CBGA are found in hemp. This means that they are legally available in most regions of the US.

You should know, however, that these cannabinoid precursors will not be found in regular CBD products. CBDA, however, can be purchased as super high-quality full-spectrum CBDA oil or as a CBD/CBDA blend right here at Myriam’s Premium Hemp Products!


CBG Oil as a Potential Treatment for Glioblastoma

Glioblastoma is a form of cancer that attacks the body either in the brain or spinal cord and usually occurs in older individuals (though it’s possible for it to occur at any age). It forms from astrocytes, (cells that support nerve cells), and can cause extreme headaches and seizures as well as nausea and vomiting. A 2021 journal collaboration entitled “Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma” was recently released detailing the research and findings of a team of Slovenian and Italian scholars from the National Institute of Biology as well as several university departments (chemical technology, experimental medicine, and neurosurgery) on the subject of CBG relevance to treating this highly aggressive cancer. While the effective use of CBG for glioblastoma hasn’t yet been fully proven, the concept is well worth looking at as a potential solution for those seeking alternative options.

CBG Oil as a potential treatment for Glioblastoma

How CBG Might Be Able to Help

Glioblastoma is denoted by histological features such as pleomorphism, vascular proliferation, and necrosis, and treatment is often very difficult. That said, the use of cannabigerol, or CBG, for glioblastoma is promising. Antecedently, both THC and CBD have been used both in solitary and in combination, but THC is often counterproductive as it can impair cognitive ability. CBG, however, is a non-toxic alternative that has demonstrated anti-tumor properties in many cases, and effectively destroys stem cells that are often resistant to treatment or therapy. It attacks glioblastoma at the base of the cancer and works to incapacitate it.

This means that CBG could act as a viable replacement for THC in the treatment of glioblastoma patients and possibly provide life-saving benefits under the right conditions. This isn’t a guarantee, and the study is still new, but advancements in this area of medicine could be promising for those who suffer from this hostile disease.

Why Do We Care So Much About CBG and Glioblastoma?

Our mother, Myriam, was diagnosed with glioblastoma in 2013 and fought hard against it. Through extensive research, we learned that cannabigerol had the potential to make a difference in her treatment, and we began to consume any information we could about manufacturing high-quality oils in an effort to relieve her pain and suffering. She provided the inspiration for us to create Myriam’s Hemp and offer hope to many others who are facing this disease. As a tribute to her memory, we continue to put passion and love into our products in the hope that we can make a difference.

Purchase CBG Oil and Other Premium CBD Products from Myriam’s Hemp

At Myriam’s Hemp our goal is to provide educational resources to help our customers find solutions that work for their lives. We’re committed to staying on top of new developments and place a special focus on producing and sourcing products that promote better health. Myriam’s Hemp CBG Oil has been developed using a proprietary strategy and contains 600mg of CBG in each fluid ounce, with a 1200mg option coming soon. Combined with an array of additional beneficial terpenes, flavonoids, and phytocannabinoids, it is intended to offer a full spectrum option for those who are seeking alternative treatment methods. We ensure that our cannabigerol oil is lab-tested, free from sugar or wheat, and contains less than 0.3% THC to give you the highest quality oil whether you’re using CBG for glioblastoma or other ailments.

We’re proud to offer a disability discount, and GBM qualifies. Purchase CBG oil online today or contact us for more information about any of our products.

The Minor Cannabinoids: Understanding CBG

There are approximately 113 different cannabinoids that have been isolated from cannabis, and those that have been studied exhibit a variety of effects 1. In the marketplace, we have access to about six:

As technology improves and companies mature, new products featuring additional cannabinoids are beginning to become available, including products with delta-8 THC, THCv, and CBC. This blog will focus on CBG.

There is little research exploring the effects of CBG—research is currently limited to in vitro (tests are done in test tubes, culture dishes, or anywhere outside of a living organism) and in rodent models—there exists no clinical research in humans. One reason that so little research exists is that CBG is not typically found in high concentrations in dried or cured cannabis plants, except in industrial hemp varieties 2.

The data that is available suggests that CBG might be effective at treating the following conditions:


A study published in 20133 stated that CBG has anti-inflammatory properties and that it could be considered as a treatment for patients suffering from intestinal bowel disease.


A 2009 study4 demonstrated that CBG might have therapeutic potential for the treatment of glaucoma as it might increase fluid drainage and decrease pressure in the eye.

Neurological Disorders

In a study completed in early 20155 CBG demonstrated neuroprotective effects in mice with Huntington’s disease (it protects and preserves the nerves of the brain from injury, disease, and degeneration). There is currently no effective treatment for Huntington’s disease. CBG might also provide neuroprotection in patients with Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke patients.


A study from 20146 demonstrated that CBG inhibited the progression of colon cancer in mice7 and another study8 suggested that CBG might also help protect from prostate cancer. A very old study9 done on mice suggested that CBG might be effective at treating skin melanoma cells.

Bladder dysfunction

A study10 done in vitro suggested that CBG was the most effective cannabinoid for treating bladder dysfunctions because it decreased bladder contractions.

Appetite Issues

CBG has been shown to increase appetite in two rat-based studies conducted by researchers at the University of Reading (UK) in 201611 and 201712.


Dr. Bonni Goldstein has suggested that CBG can decrease anxiety and muscle tension, and appears to have antidepressant and some modest antifungal properties.

Erectile dysfunction

CBG might be a treatment for sexual dysfunction in men. Of course, reasons for sexual dysfunction are complex, and the current research is very limited.

Additionally, Radicle Health patients have reported success when using CBG to help treat anxiety, migraines, mild pain, and hot flashes.

Overall, CBG is very safe. It has no impairing effects, no toxic dose, no withdrawal effects, and no risk of addiction. CBG can be a safe option for use in pediatric and geriatric populations and in patients with a history of psychosis or schizophrenia.


CBG vs CBD: What Are The Differences?

When most people think of cannabinoids, they usually think of THC and CBD. THC is known for giving the psychoactive effects you’d generally associate with cannabis, while CBD is known for its medical qualities. However, cannabis and hemp plants are made up of many more cannabinoids which have their own beneficial effects. One of these is CBG. So what is CBG and what’s the difference when it comes to CBG vs CBD?

CBD and CBG are actually fairly similar. Both are non-psychoactive cannabinoids you can find in hemp and cannabis plants which offer a range of medical benefits when consumed. While CBD is more popular by far, CBG also has a range of effects that can help with many symptoms. So how do they differ and which is better for you? Here’s a guide to CBG vs CBD.

CBG and CBD are two entirely different cannabinoids with different chemical structures and different effects on the body. However, they are similar in many ways. Both of these are compounds found in marijuana and hemp plants. They can also be extracted from plants and consumed to get a range of positive health effects.

CBD, THC, and other cannabinoids actually start as CBG. CBG is often found early during a hemp plant’s growth and is later converted into different chemical structures. However, it can be extracted early to create medical cannabigerol products. Much like with CBD and other cannabinoids, it can be infused into oil and other forms for consumption.

Much like with CBG, CBD is a cannabinoid that’s often extracted from both cannabis and hemp plants for medical use. It’s found in high quantities in these plants and is therefore extremely popular and easy to find. While both of these cannabinoids interact with the body to offer various effects, their medical benefits do differ from one another somewhat.

Benefits of CBG

Much like CBD, CBG has various positive health effects for the body when consumed. While it can offer similar benefits to CBD, cannabigerol is more effective for certain health issues.

Research also shows that cannabigerol has potent pain-relieving effects. It can also help with cancer- it’s shown to increase appetite in patients and can even block the growth of cancer cells according to a 2014 study.

It can also help with eye conditions. Research shows it can help reduce intraocular eye pressure, which is particularly helpful for glaucoma. CBG also has neuroprotective qualities and can help with various neurological disorders. One study found that it could help protect brain health and prevent cell degeneration.

A study also found that CBG is better than other cannabinoids for preventing muscle contractions. This is helpful for those with bladder issues. CBG also has antibacterial and anti-inflammatory effects, making it useful for a range of conditions and symptoms.

Where To Buy CBG & CBD

Both CBG and CBD are extracted by plants for use in medical products. You can buy these and use them to get the medical benefits of cannabinoids. While cannabis-based products are still illegal in many parts of the states, you can legally buy hemp products anywhere. This makes all of the products on Myriam’s Hope Hemp legal to order for delivery for US customers.

You can buy CBD Oil online in various quantities. If you’re only using CBD for general use, a 750mg bottle with a daily dosage of 25mg should do you fine. If you want to use it for a long time or just want to take more CBD, you’ll benefit more from Daily 50 CBD or even Daily 100 CBD which contains 3000mg in each bottle.

Likewise, you can also buy CBG Oil online. These products are made with 600mg of CBG extracted from hemp, making them very safe and legal to use.

How To Use CBG & CBD Oil

You use cannabigerol and CBD Oil in the same way. Fortunately, they’re very simple to use for people of all ages and conditions.

Each bottle comes with a dropper that contains a certain amount of oil. You use this to apply the oil under your tongue. Hold the oil under your tongue for around 30 seconds to a minute. This will absorb the cannabinoids into your body, where they’ll take effects.

These products absorb and work fast. In some cases, you’ll get the effects you need immediately, such as pain and anxiety relief. Some effects of CBD/CBG take a while to build up in your body, so taking regular daily dosages is recommended for various symptoms.

CBG vs CBD: Which Should You Use?

So when it comes to the choice of CBG vs CBD, which is better for you? Both of these cannabinoids have many benefits, and even provide some of the same effects such as pain relief and boosting appetite. Cannabigerol may be better for eye conditions and bladder issues. CBD is more commonly used for things like anxiety, depression, and preventing seizures.

Both can be effective for reducing pain, treating cancer, and protecting brain health. CBD and CBG can actually work best in unison with each other. Using both together is safe and has an ‘entourage effect’, with both giving you a ton of overall benefits to improve and protect your health.

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