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Let’s Talk CBN

Let's Talk CBN

Published March 1, 2023
Reading Time 5 Minutes

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Many cancer patients are cannabinoid users, whether for recreation or as a therapeutic supplement/addition to their regular cancer treatment. Hemp has many uses for cancer patients, and in fact, two of the only three FDA-approved hemp-based medications (Marinol and Syndros) are prescribed to patients who have nausea and vomiting related to chemotherapy. 

 

However, there is much more to cannabinoid use for cancer than those two medications. Several of the minor cannabinoids show great promise for relieving cancer symptoms. One of these cannabinoids is cannabinol or CBN.

What Is CBN?

CBN is a minor cannabinoid that is found in hemp plants. It is formed from the degradation of tetrahydrocannabinol (THC), so it will be found in higher concentrations in aged cannabis plants. CBN is a non-intoxicating cannabinoid, so it will not get you high, and it is of great interest to the hemp research community for its potential therapeutic properties. If you would like to know more about CBN, we have a full guide to it here; today we are going to be looking specifically at its relationship to cancer.

Using CBN for Cancer

Generally speaking, CBN can have numerous benefits for patients with varying types of cancer. One of its main benefits is the effect it can have on pain. Studies have shown that CBN has a painkilling effect for both short-term and chronic pain. Pain management is an important part of cancer recovery, and many patients want to avoid the negative side effects of synthetic painkillers. CBN and other cannabinoids with an analgesic effect may be of great benefit to these patients.

 

Another major benefit of CBN to cancer patients is its role as an appetite stimulant. Many cancers and cancer medications cause increased nausea and a decreased appetite, which makes it hard to get good nutrition and enough calories to support recovery. But a 2012 study found that CBN increased both appetite-related behaviors and eating-related behaviors, including increases in meal sizes and meal durations. 

 

CBN may also be a broadly anti-cancer treatment due to its ability to induce apoptosis, or cell death, in certain types of cancer cells. There are two ways that this can occur. One way is related to the reaction of IL-2, a signaling molecule in the immune system when exposed to CBN. 

 

When this signaling molecule is exposed to CBN, the cell replication process experiences disruption and there is a modulation of the immune response that causes delayed cell replication and apoptosis in some cancer cells. 

 

The other way that CBN induces apoptosis involves cell signaling pathways, specifically the AKT  and ERK pathways. These pathways play an important role in regulating various cellular processes, including cell growth, replication, survival, and metabolism. 

 

There is evidence that when the AKT pathway activates incorrectly, there are strong implications for the development and progression of cancer. This has led cancer researchers to look for ways to target the AKT pathway specifically when developing new therapies for cancer. 

 

Because CBN can inhibit the AKT pathway and induce apoptosis and autophagy (a condition where the cell “eats” itself, depleting itself of nutrients and restricting growth and development), it is a promising therapy for many types of cancers. 

CBN for Brain Cancer

The first type of cancer cells that the AKT researchers looked at were glioma cells. Glioma is a type of brain cancer that arises from the cells that support and protect neurons (nerve cells) in the brain and spinal cord. Research has shown that CBN has multiple avenues of neuroprotection, which can help keep these cells healthy, to begin with.

CBN for Liver Cancer

The pathway study also included liver cancer cells. Much like with the glioma cells, the liver cancer cells were effectively inhibited by the presence of CBN. However, while the brain cancer cells had their AKT pathways activated, the mechanism for fighting liver cancer was slightly different and used the ERK pathways instead.

 

This is not the only time that CBN has been shown to be effective against liver cancer. Another study found that CBN can activate the ERK pathways in liver cells, inhibit cellular communication, and block cellular proliferation. This means that it can help stop cancer cells from replicating and spreading, which can directly impact tumor growth.

CBN for Breast Cancer

Breast cancer was the third cancer type included in the pathway study. However, this is not the only study to find ways that CBN has potential as a treatment method for breast cancer. A mixture of cannabinoids, including CBN, has been found to be effective against breast cancer cells while leaving healthy breast tissue cells alone. 

 

CBN has another important link to breast cancer treatment, and that is its ability to reduce the concentration of Breast Cancer Resistance Protein (BCRP, also known as ABCG2) that a cancer patient produces. While normally you want good concentrations of BCRP, as it protects against harmful compounds, BCRP is a drug efflux pump– and that’s a problem if you are receiving chemotherapy.

 

A drug efflux pump is a protein that pumps foreign substances (like medication) out of cells. This type of protein is one of the mechanisms that allow cancer cells to resist chemotherapy. It prevents the chemotherapy drugs from accumulating in the cancer cells, making them less effective. Research has shown that CBN is an effective inhibitor of this protein. When resistant cells were exposed to CBN, they were resensitized to the chemotherapy drugs that they had begun to resist. This suggests that CBN may help chemotherapy for breast cancer be more effective.

How To Use CBN

If you or a loved one is struggling with brain cancer, liver cancer, or breast cancer, and you want to see if CBN is right for you and can help manage your symptoms, the easiest way to get an effective dose is by using a tincture. Our CBN tincture products available at Myriam’s Hemp are made using premium hemp extracts and are administered under the tongue using a standard dropper syringe.

 

As always, we strongly recommend consulting with a cannabis medical professional for proper product guidance and dosing regimen. If you would like a referral to a reputable Cannabis Doctor, please contact us at (800) 683-4807 ext 0 or email us at support@myriamshemp.com.

At Myriam’s Hemp, we believe that everybody should have access to the information they need to make choices about their health. A cancer diagnosis is often overwhelming, and we want to help you explore your options for relief. Contact us today if you have any questions about our premium CBN and other cannabinoid products.

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Can CBD Help You Maintain a Healthy & Comfortable Weight?

Can CBD Help You Maintain a Healthy & Comfortable Weight?

Published January 31, 2023
Reading Time 5.2 Minutes

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There are many reasons why people are interested in taking CBD. Because CBD interacts with receptors all throughout the body, it can impact many elements of your health and wellness. One area of wellness that many people struggle with is weight, and as a result, many people want to know if CBD can help them maintain their desired weight.

 

We’d like to start by saying that we know that weight is a sensitive issue for many people. We don’t want to make anybody uncomfortable with this article; your weight is your business and people with bodies of all sizes deserve to be happy and treated respectfully. Weight is a complicated subject; in addition to your body’s natural size and genetic predispositions, weight can be impacted by stress, nutrition, mental welfare, and so much more. 

 

This article exists because we want to share how CBD can help you address some of these underlying conditions to feel more comfortable and confident in your own skin.

How Can CBD Help You Manage Your Weight?

There is some evidence that CBD can interact directly with your metabolism. For example, two animal studies indicate that CBD can affect weight by interacting with CB1 and CB2 receptors in lymphoid tissue and the brain. These receptors are thought to play important roles in metabolism and food intake. However, this CBD was injected– not the way people normally take it.

 

Instead, when people take CBD for weight management, it is usually part of a holistic method that addresses some of the conditions that can cause unwanted weight loss or weight gain. There are many factors that contribute to the challenge of maintaining your desired weight. Several of these factors are impacted by CBD. 

CBD for Unwanted Weight Gain

Research has found that CBD does not have a direct impact on weight loss. However, when you look at the underlying causes of unwanted weight gain, there are areas that CBD may be able to help with. 

 

CBD and other cannabinoids work by interacting with the body’s endocannabinoid system. This system is dispersed throughout the body and responds to different chemicals through two cannabinoid (CB) receptors, called the CB1 and CB2 receptors. CB1 receptors are most dense in the brain and central nervous system, while CB2 receptors are found mainly in the immune system.


However, CB1 receptors are also widespread in adipose tissue. CBD works with other cannabinoids to potentially activate many receptors in these tissues, such as endocannabinoids and serotonin. This may play a role in various metabolic functions. Specifically, CB1 receptor agonists that deactivate or block off the receptor may help reduce appetite, while stimulating CB2 receptors decreases inflammation and may reduce food intake, which can help prevent unwanted weight gain. 

 

Additionally, CBD can help with many of the underlying conditions that lead to unwanted weight gain such as stress and anxiety, inflammation, sleep, and more. 

Stress and Anxiety

Research shows that there is a link between stress and weight gain, and stress and anxiety play an even bigger role in the body’s condition than you might think.

 

While everybody experiences stress, prolonged, chronic stress can be extremely harmful. Chronic stress promotes a number of harmful conditions, including…

Chronic or repeated stress is especially harmful and is a major factor in exacerbating mental illnesses such as anxiety disorders and depression. Long-term stress also leads to heightened levels of the hormone cortisol. Long-term elevated cortisol levels cause your body to raise insulin levels, which drops blood glucose levels and typically increases the intake of high-calorie foods. These foods cause the body to release dopamine and serotonin, which have a calming effect and can help ameliorate stress– but at the same time can cause unwanted weight gain. Research shows that CBD’s effect on the CB1 receptors may be able to help interrupt this cycle.

Inflammation

Weight and inflammation can also play a simultaneous role in nonalcoholic liver disease and its effects on the body. One popular use of CBD is to fight inflammation in the body’s tissues; one derivative of CBD even shows great promise in rodent studies of liver inflammation specifically. 

Research shows that there is a link between unwanted weight gain, inflammation, and the gut microbiome. CBD has been shown to reduce intestinal inflammation, which helps bring these factors into balance. CBD and other cannabinoids have also been found to stabilize the blood-brain barrier and reduce both gut inflammation and inflammation in the brain. Inflammation in both the gut and brain can adversely affect brain health and function. 

Sleep

Getting regular, high-quality sleep is vital to maintaining your desired weight. Getting less than six hours of sleep per night is linked to higher weight in adults. CBD is known to increase total sleep time, and many users of CBD report better periods of sleep and better periods of wakefulness, suggesting that CBD may help create better sleep balance.

CBD for Unwanted Weight Loss

Unwanted weight loss is often a problem for people who are suffering from conditions like HIV or cancer. If you are managing symptoms that include undesirable weight loss, CBD may be able to help by relieving nausea. 

At Myriam’s Hemp, our goal is to help people take charge of their health and wellness in ways that the pharmaceutical industry does not address or engage with. We want to help you take control of your health by offering premium CBD products that we believe in. Weight management, whatever that might mean for you, can have a significant impact on your life, and we want to help you live comfortably. Our CBD products are created with quality at the forefront and we are constantly striving to enhance our offerings. 

 

Shop Myriam’s Hemp online and order your CBD today.

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Beginner’s Guide to CBD for Autistic Children

Beginner’s Guide to CBD for Autistic Children

Published January 5, 2023
Reading Time 5.3 Minutes

Photo by Jordan Whitt on Unsplash

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As the parent of a child with autism spectrum disorder (ASD), it can be challenging to know which therapies, treatments, and resources will help or hinder your child. No two Autistic children are quite alike, but it can feel like you as the parent are expected to follow a prescribed set of rules for parenting your kiddo. 

In this blog, we’ll be discussing the use of CBD and medical cannabis therapy for Autistic kids, but we’ve got a very important message to share first. 

Accepting Autistic kids for who they are is one of the most vital parts of cultivating their confidence, happiness, and long-term health. You as a parent may feel pressure to push back against quirks and unwanted behaviors, but it’s important to remember that kids with ASD are never trying to upset you on purpose. 

The use of CBD for Autistic kids is to help alleviate symptoms often associated with ASD like anxiety, depression, and sensory sensitivities. The result is often reduced behavioral outbursts, fewer mood swings, and increased comfort in social situations. However, CBD alone can’t give your Autistic child everything they need to thrive. 

As a parent, you’ll also need to provide other forms of support, confidence, and accessibility resources for your Autistic child. To connect with and learn more from parents of Autistic kids who use medical cannabis products to support their children, visit the Whole Plant Access for Autism Support Group on Facebook or visit their website at HERE.

How CBD Works for Kids with Autism

CBD has been found to interact with nerve cell messages in regions of the brain regulating anxiety, executive function, and behavior, blocking signals to key neuroreceptors that can trigger seizures– all of which are symptoms of ASD. 

CBD isn’t going to change your child’s personality, but what it may do is bring them relief from the painful and debilitating symptoms of ASD, like seizures, depression, and anxiety.

CBD Pushes Biomarkers to “Typical” Levels 

A novel way of looking at ASD is to look at biomarkers. Biomarkers are characteristics of the body that you can measure; they range from something as simple and easy to understand as heart rate to far more complex internal measurements. 

For autism, there are several genes, proteins, peptides, and metabolites that can be used as biomarkers for ASD. One very promising element of CBD for ASD treatment is that many of these biomarkers interact with the endocannabinoid system; as a result, CBD use can push these biomarkers toward a more neurotypical level. Biomarkers can provide direct evidence for the success of CBD as an autism treatment.

CBD vs. Pharmaceutical Therapies

Autistic children are frequently prescribed lots of pharmaceutical drugs. These typically include SSRI antidepressants, antipsychotics, anticonvulsants, stimulants, tricyclics, and anti-anxiety medications. 

While these medications can work, they might not be what your child needs. These drugs have a number of side effects and interactions with each other and with other common medical treatments and may have serious risks involved with their use. 

It is these risks that often lead parents to seek out alternative forms of treatment. CBD is frequently favored because the side effects are mild—if present at all—and are typically short-lived. 

Benefits of CBD for Autistic Children

Overall, CBD shows several promising benefits for autistic kids. A 2018 study on the efficacy of CBD for relieving ASD symptoms showed that a notable percentage of the subjects experienced significant improvement in various areas, including communication, behavioral, and anxiety issues. 

In another two-year study, behavioral problems were the symptom that saw the greatest reduction after treatment with CBD. CBD interacts with several parts of the brain and nervous system that are linked to ASD symptoms, so it shows great promise as a treatment for autistic kids.

Is CBD Safe for Kids?

CBD is generally considered safe. The World Health Organization has also found that CBD is generally well-tolerated and has a good safety profile. The FDA has even approved an epilepsy drug derived from CBD.

When it comes to medications, remember that “safe” is balanced against efficacy. When you consider the side effects of many of the pharmaceutical drugs prescribed to autistic kids, the extremely rare, mild side effects of CBD seem much safer.

How Is CBD Different From Medical Marijuana? 

CBD and medical marijuana are two very different things. CBD is a chemical compound found in the cannabis plant. Unlike the psychoactive compound THC, CBD does not have psychoactive effects, meaning it does not produce a “high” or altered state of consciousness. 

Medical marijuana refers to the use of the whole cannabis plant or its extracts to treat certain medical conditions. The main active ingredient in medical marijuana is THC, although it may also contain varying amounts of CBD depending on the strain.

How Much CBD Should Kids with Autism Take?

Dosing CBD can be tricky because if you dose too much or too little, you don’t get the full benefits. Our recommendation is always to consult with a qualified cannabis medical professional before administering hemp products to your child.

Risks of Using CBD for Autism

There is very little risk in using CBD for autism. CBD may have some minor side effects like diarrhea, changes in appetite, and fatigue. These are rare and frequently go away once the body is used to CBD.

How To Purchase CBD for Autistic Kids

We understand that trying something new for your autistic kid can be simultaneously promising and terrifying. Making health decisions for your child is never easy, and we really understand that. When we started Myriam’s Hemp, one of our goals was to simplify the process of getting cannabinoid products for medical concerns. We want to help your family, too. 

It is common for parents to start their children with a lower potency CBD and work up to a higher concentration. It’s also very common to use a variety of cannabinoids to help enhance the effects of their child’s needs.

Although our products come with a basic suggested starting usage guide, we strongly recommend consulting with a cannabis doctor to help you with proper product recommendations and dosing guidance. If would like guidance from a cannabis medical professional, we would be happy to refer you to a cannabis doctor or nurse. If you are considering CBD to help your autistic child, please do not hesitate to reach out to our friendly, knowledgeable support staff. Please contact us by email at support@myriamshemp.com or phone at (800) 683-4807 ext 0 for a cannabis doctor or nurse referral or any questions about our products.

CBD can help with the most debilitating symptoms of autism, letting your child’s individuality and personality shine. At Myriam’s Hemp, we are here to help families with their loved one’s health journey. 

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CBD for Men’s Health

CBD for Men's Health

Published July 13, 2022
Reading Time 5 Minutes

Photo by Derek Owens on Unsplash

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Anybody can benefit from CBD’s numerous health-enhancing properties. If you’re a man who has concerns about your health and wellness, and you’ve been wondering what this compound can do for you, we hear you. There are many benefits of CBD for men, no matter what kind of health answers you’re seeking.

CBD For Heart Health

According to the CDC, heart disease is the number one cause of death for men. About one in every four male deaths is linked to heart disease, so taking your cardiac health into consideration is important. 

CBD is both a natural anti-inflammatory and antioxidant, both of which make it beneficial for heart health. In recent animal studies, CBD was shown to significantly reduce cardiac dysfunction. CBD can also help prevent heart problems before they start, as it is naturally cardioprotective. Stress also plays a big part in our heart health, Thankfully, CBD is proven to be beneficial for improving the way our bodies respond to stress by reducing resting blood pressure with its calming properties.

CBD For Sexual Wellness

The idea of cannabinoid use for sexual dysfunction isn’t a new concept. It has been a feature of Ayurvedic medicine for thousands of years! Sexual health and wellness are tied to overall bodily health. Conditions like erectile dysfunction and low libido can be linked to stress, anxiety, depression, and other mental health conditions– which we’ll talk about more in a bit. But they can also be linked to physical issues with blood flow.

One of the reasons that CBD is helpful for sexual wellness concerns is that it’s a vasodilator. CBD dilates your veins and makes it easier for blood to reach erectile tissues in your genitalia. When you combine proper blood flow with improved mental health, you’ll see why many people have had success when taking CBD for erectile dysfunction, low sex drive, or any other trouble with arousal.

CBD For Mental Health

Did you know that men are less likely than women to seek mental health treatment? There is an unfortunate stigma around seeking help for mental health problems, whether that’s depression, anxiety, stress, or any other mental health concern. CBD is growing increasingly popular as a mental health treatment; a major CBD marketplace survey showed almost 1 in 5 CBD users hoped to address anxiety.

CBD For Anxiety

Almost one in three adults in the US will struggle with an anxiety disorder at some point in their life. For men, that number is more than one in four. Anxiety is the most common mental health concern men face, and it’s a concern that can be addressed with CBD. While CBD doesn’t have the psychoactive effects that other cannabinoids may have, it does interact with the endocannabinoid system receptors and can directly impact the areas of the brain that create anxiety responses. 

Patient responses also reflect the clinical understanding of what CBD can do for mental health. In a medical response audit of the first 400 medical CBD patients in New Zealand, the patients who were receiving CBD for anxiety all reported improvements in their ability to perform daily functions and reduced anxiety symptoms. In another recent study, CBD was shown to be widely effective for men with anxiety; although the study was cross-sectional by sex, the majority of anxiety patients just happened to be men. CBD was effective at relieving anxiety symptoms in about 80% of study participants in the first two months!

CBD For Stress

Stress management is a challenge that many men face. It’s especially important to address stress because studies suggest that long-term stress greatly increases the risk of heart disease. Stress frequently goes hand-in-hand with anxiety, and long-term stress can lead to numerous mental and physical health conditions. 

However, when you’re able to manage your stress, you’re likely to see notable improvements in all aspects of your health and wellness, including the immune system, blood pressure, gut health, and the quality of the sleep you get. These are just some of the many reasons that managing your stress is good for you.

The same endocannabinoid system receptors that control anxiety responses also engage when we’re experiencing stress. This means that when you take CBD when you’re stressed, it engages with those receptors the same way it does for people dealing with the symptoms of anxiety. CBD has been shown many times to be effective in reducing the physiological symptoms of stress in animal models, and many people have reported positive effects on their stress levels after taking CBD.

CBD For Brain Health

Additionally, CBD can help with overall brain health. As a vasodilator, CBD helps promote healthy blood flow. In one human study, a single dose of CBD increased blood flow to the hippocampus, an area of the brain associated with memory and emotion. The researchers were enthusiastic about CBD’s potential for treating conditions that affect memory processing, such as PTSD, Alzheimer’s disease, and schizophrenia.

CBD For Recovery

Men are more likely to be injured than women. No matter what kind of injury you’re looking at, men typically engage in more behavior that exposes them to injury risk and experience more injuries overall. There are several potential reasons proposed for this, but if you’ve experienced an injury, it’s likely that at the moment, you didn’t really care much about why you were hurt– you just wanted the hurting to stop!

CBD is helpful for recovery, both from accidental injury and for muscle recovery after working out. When you work out, you’re putting wear and tear on your muscles. It’s more controlled than what happens when you injure yourself, but it can still cause pain and inflammation– and injury if you’re not being careful! Fortunately, CBD is a natural anti-inflammatory. It also promotes improved bone density and collagen production, making it a natural choice for recovery assistance. 

At Myriam’s Hemp, we believe that everybody should have access to the information they need to make choices about their health. There are many aspects of men’s health that our premium CBD products can help address! If you need help choosing the right product, Myriam’s Hemp is here to help you explore your options for better relief. 

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